Nuclear Medicine and Molecular Imaging

, Volume 50, Issue 1, pp 24–30 | Cite as

Correlation between Semi-Quantitative 18F-FDG PET/CT Parameters and Ki-67 Expression in Small Cell Lung Cancer

  • Soyeon Park
  • Eunsub Lee
  • Seunghong Rhee
  • Jaehyuk Cho
  • Sunju Choi
  • Sinae Lee
  • Jae Seon Eo
  • Kisoo Pahk
  • Jae Gol Choe
  • Sungeun KimEmail author
Original Article



The aim of this study was to evaluate the relationship between semiquantitative parameters on 18F-FDG PET/CT including maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) and the expression level of Ki-67 in small-cell lung cancer (SCLC).


Ninety-four consecutive patients with SCLC were enrolled in this study. They underwent 18F-FDG PET/CT for initial evaluation of SCLC, and we measured SUVmax, avgSUVmean, MTVsum, and TLGtotal on 18F-FDG PET/CT images. The protein expression of Ki-67 was examined by immunohistochemical staining.


Significant correlations were found between the MTVsum and Ki-67 labeling index (r = 0.254, p = 0.014) and the TLGtotal and Ki-67 labeling index (r = 0.239, p = 0.020). No correlation was found between the SUVmax and Ki-67 labeling index (r = 0.116, p = 0.264) and the avgSUVmean and Ki-67 labeling index (r = 0.031, p = 0.770). Dividing the Ki-67 expression level into three categories, it was suggested that increasing Ki-67 expression level caused a stepwise increase in the MTVsum and TLGtotal. (p = 0.028 and 0.039, respectively), but not the SUVmax and avgSUVmean (p = 0.526 and 0.729, respectively).


In conclusion, the volume-based parameters of 18F-FDG PET/CT correlate with immunohistochemical staining of Ki-67 in SCLC. Measurement of the MTVsum and TLGtotal by 18F-FDG PET/CT might be a simple, noninvasive, and useful method to determine the proliferative potential of cancer cells.


Small-cell lung carcinoma 18F-FDG PET/CT Metabolic tumor volume Ki-67 



This study was funded by a Korea University Special Research grant, Korea University, Seoul, South Korea (no. K1507831).

Compliance with ethical standards

Conflict of Interest

Soyeon Park, Eunsub Lee, Seunghong Rhee, Jaehyuk Cho, Sunju Choi, Sinae Lee, Jae Seon Eo, Kisoo Pahk, Jae Gol Choe, and Sungeun Kim declare that they have no conflict of interest.

Ethical Statement

This study protocol was approved by the International Review Board for Research on Human Subjects at our hospital. All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation and with the Helsinki Declaration of 1975, as revised in 2000. Informed consent was waived.

The manuscript has not been published before and is not under consideration for publication anywhere else and has been approved by all coauthors.


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Copyright information

© Korean Society of Nuclear Medicine 2015

Authors and Affiliations

  • Soyeon Park
    • 1
  • Eunsub Lee
    • 1
  • Seunghong Rhee
    • 2
  • Jaehyuk Cho
    • 2
  • Sunju Choi
    • 2
  • Sinae Lee
    • 3
  • Jae Seon Eo
    • 1
  • Kisoo Pahk
    • 2
    • 4
  • Jae Gol Choe
    • 2
  • Sungeun Kim
    • 2
    Email author
  1. 1.Department of Nuclear MedicineKorea University Guro HospitalSeoulSouth Korea
  2. 2.Department of Nuclear MedicineKorea University Anam HospitalSeoulSouth Korea
  3. 3.Department of Nuclear MedicineG Sam HospitalGunpoSouth Korea
  4. 4.Department of Neuroscience, College of MedicineKorea UniversitySeoulSouth Korea

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