Coexistence of Hashimoto’s thyroiditis and papillary thyroid carcinoma
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The coexistence of Hashimoto’s thyroiditis (HT) and papillary thyroid carcinoma (PTC) has been a widely debated issue. In view of the current controversy, as well as the high prevalence of both diseases, the objective of the present paper is to evaluate the association between them and to propose the proper therapeutic management.
We herein review previous pertinent literature on the subject of concomitant HT and PTC, with respect to epidemiology, clinical presentation, carcinogenesis, and appropriate treatment.
Studies to date establish 6.5-43.8% of patients with PTC and coexisting HT, while 11-58.3% of all HT patients will develop PTC. Coexistence of the diseases is significantly related to younger women. Malignant lesions tend to be microcarcinomas, at times multifocal (13.5-44%) and occasionally metastasising to the central cervical compartment (10.8-49%). Mostly, patients have a good prognosis with total thyroidectomy, accompanied by central compartment node dissection in cases with nodal involvement. Many issues, including molecular biological characteristics of carcinogenesis in Hashimoto’s thyroiditis, remain to be clarified and further studies need to be undertaken.
The close relationship between HT and PTC lends credence to the hypothesis that autoimmune thyroiditis is a predisposing factor to the development of thyroid carcinoma but patients tend to have favorable clinicopathological characteristics and long recurrence-free survival. A careful surveillance of these patients is required for an early detection of malignant lesions, which should constitute indication for radical surgical treatment.
Key wordsHashimoto’s thyroiditis papillary thyroid carcinoma epidemiology clinical presentation carcinogenesis treatment
- AGES scoring system
Age of the patient, histological Grade of the tumor, Extent of the tumor (extrathyroidal invasion or distant metastases), Size of the primary tumor
- AMES scoring system
Age of the patient, presence of distant Metastases, Extent of the primary tumor, Size of the primary cancer
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