Hellenic Journal of Surgery

, Volume 82, Issue 4, pp 224–232 | Cite as

The role of functional foods in the prevention of colorectal cancer

Review Article


Conclusively, studies on the possible beneficial effect of specific types of food or of adding supplements like calcium and vitamin D to the daily diet have somewhat equivocal results. It is not possible to conclude with certainty whether a low fat diet with increased fibre, fruit and vegetables has a particular benefit in preventing colon cancer. The same applies to the effect of calcium and vitamins C and D.

Key words

Functional food Colorectal cancer Prevention of 


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  1. 1.
    Jemal A, Siegel R, Ward E et al. Cancer statistics. CA Cancer J Clin 2007; 57:43–66CrossRefPubMedGoogle Scholar
  2. 2.
    Weir HK, Thun MJ, Hankey BF et al. Annual report to the nation on the status of cancer, 1975–2000, featuring the uses of surveillance data for cancer prevention and control. J Natl Cancer Inst 2003; 95:1276–1299PubMedGoogle Scholar
  3. 3.
    Peto R. Cancer, cholesterol, carotene, and tocopherol. Lancet 1981;2:97–98CrossRefPubMedGoogle Scholar
  4. 4.
    Peto R, Doll R, Buckley JD, Sporn MB. Can dietary betacarotene materially reduce human cancer rates? Nature 1981; 290:201–208CrossRefPubMedGoogle Scholar
  5. 5.
    Rock CL. Nutritional factors in cancer prevention. Hem Oncol Clin N Am 1998;12:975–991CrossRefGoogle Scholar
  6. 6.
    Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990;61:759–767CrossRefPubMedGoogle Scholar
  7. 7.
    Hursting SD, Slaga TJ, Fischer SM et al. Mechanism-based cancer prevention approaches: targets, examples, and the use of transgenicmice. J. Natl. Cancer Inst 1999; 91:215–225CrossRefPubMedGoogle Scholar
  8. 8.
    Waterland RA, Jirtle RL. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol 2003; 23(5):5293–5300CrossRefPubMedGoogle Scholar
  9. 9.
    Chemoprevention Working Group. Prevention of cancer in the next millennium: Report of the Chemoprevention Working Group to the American Association for Cancer Research. Cancer Res 1999; 59:4743–4758Google Scholar
  10. 10.
    Sporn MB. Approaches to prevention of epithelial cancer during the preneoplastic period. Cancer Res 1976; 36:2699–2702PubMedGoogle Scholar
  11. 11.
    Rosen GM, Britigan BE, Halpern HJ, Pou S. Free radicals. Biology and detection by spin trapping. Oxford University Press, New York, Oxford, 1999Google Scholar
  12. 12.
    Vaya J, Aviram M. Nutritional antioxidants: mechanisms of action and medical applications, Current Medicinal Chemistry-Immunology Endocrinology and Metabolic Agents 2001;(1):99–117Google Scholar
  13. 13.
    Wardman P. Indole-3-acetic acids and horseradish peroxidase: a new prodrug/enzyme combination for targeted cancer therapy. Current Phar Des 2002; 8:1363–1374CrossRefGoogle Scholar
  14. 14.
    The Alpha-Tocopherol Beta-Carotene cancer prevention study group. The effect of vitamin E and beta-carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994; 330:1029–1035CrossRefGoogle Scholar
  15. 15.
    Lee SH, Oe T, Blair IA. Vitamin C-induced decomposition of lipid hydroperoxides to endogenous genotoxins. Science 2001;292:2083–2086CrossRefPubMedGoogle Scholar
  16. 16.
    5-A-Day website: www.5aday.comGoogle Scholar
  17. 17.
    Goldberg I. Functional foods, Pharmafoods, Nutraceuticals. A Chapman & Hall Food Science Book, Aspen Publishers, 1999Google Scholar
  18. 18.
    Goldberg I. Functional foods, Pharmafoods, Nutraceuticals. A Chapman & Hall Food Science Book, Aspen Publishers, 1999Google Scholar
  19. 19.
    Davidson MH, McDonald A. Fiber: forms and functions. Nutrition Research 1998;18(4):617–624CrossRefGoogle Scholar
  20. 20.
    Hill MJ. Cereals, dietary fibre and cancer. Nutrition Research 1998; 18(4):653–659CrossRefGoogle Scholar
  21. 21.
    Fitch Haumann B. Nutritional aspects of n-3 fatty acids. Inform 1997;8(5):428–447Google Scholar
  22. 22.
    Dillard CJ, German JB. Phytochemicals: neutraceticals and human health. J Science Food Agriculture 2000;80(12):1744–1756CrossRefGoogle Scholar
  23. 23.
    Anand P, Kunnumakara BA, Sundaram C et al. Cancer is a preventable disease that recquires major lifestyle changes. Pharmaceutical Research 2008;25(9):2097–2116CrossRefPubMedGoogle Scholar
  24. 24.
    Kushi HL, Byers T, Doyle C et al. American cancer society guidelines on nutrition and physical activity for cancer prevention: reducing the risk of cancer with healthy food choices and physical activity. CA Cancer J Clin 2006;56:254–281CrossRefPubMedGoogle Scholar
  25. 25.
    M.R. Forman, S.D. Hursting, A. Umar, J.C. Barrett. Nutrition and cancer prevention:A Multidisciplinary Perspective on Human Trials. Annu Rev Nutr 2004;24:223–254CrossRefPubMedGoogle Scholar
  26. 26.
    MacLennan R, Macrae F, Bain C et al. Randomized trial of intake of fat, fiber, and beta carotene to prevent colorectal adenomas. The Australian Polyp Prevention Project. J. Natl. Cancer Inst. 1995; 87:1760–1766CrossRefPubMedGoogle Scholar
  27. 27.
    Slattery ML, Curtin K, Anderson K et al. Associations between cigarette smoking, lifestyle factors, andmicrosatellite instability in colon tumors. J. Natl. Cancer Inst. 2000; 92:1831–1836CrossRefPubMedGoogle Scholar
  28. 28.
    Schatzkin A, Lanza E, Corle D et al. Lack of effect of a lowfat, high-fiber diet on the recurrence of colorectal adenomas. Polyp Prevention Trial Study Group. N. Engl. J.Med. 2000; 342:1149–1155CrossRefPubMedGoogle Scholar
  29. 29.
    Craig WJ. Phytochemicals: guardians of our health. J Am Diet Assoc 1997; 79(Suppl. 2):S199–204CrossRefGoogle Scholar
  30. 30.
    Fuchs CS, Giovannucci EL, Colditz GA et al. Dietary fiber and the risk of colorectal cancer and adenoma in women. N Engl J Med 1999;340:169–176CrossRefPubMedGoogle Scholar
  31. 31.
    Michels KB, Edward G, Joshipura KJ et al. Prospective study of fruit and vegetable consumption and incidence of colon and rectal cancers. J Natl Cancer Inst 2000; 92:1740–1752CrossRefPubMedGoogle Scholar
  32. 32.
    Peters U, Sinha R, Chatterjee N et al. Dietary fibre and colorectal adenoma in a colorectal cancer early detection programme. Lancet 2003; 361:1491–1495CrossRefPubMedGoogle Scholar
  33. 33.
    Bingham SA, Day NE, Luben R et al. Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC):an observational study. Lancet 2003; 361:1496–1501CrossRefPubMedGoogle Scholar
  34. 34.
    Koushik A, Hunter DJ, Spiegelman D et al. Fruits, vegetables and colon cancer risk in a pooled analysis of 14 cohort studies. J Natl Cancer Inst 2007;99(19):1471–1483CrossRefPubMedGoogle Scholar
  35. 35.
    Baron JA, Beach M, Mandel JS et al. Calcium supplements for the prevention of colorectal adenomas. Calcium Polyp Prevention Study Group. N Engl J Med 1999; 340:101–107CrossRefPubMedGoogle Scholar
  36. 36.
    Bonithon-Kopp C, Kronborg O, Giacosa A et al. Calcium and fibre supplementation in prevention of colorectal adenoma recurrence: a randomised intervention trial. European Cancer Prevention Organisation Study Group. Lancet 2000; 356:1300–1306CrossRefPubMedGoogle Scholar
  37. 37.
    Hofstad B, Almendingen K, Vatn M et al. Growth and recurrence of colorectal polyps: a double-blind 3-year intervention with calcium and antioxidants. Digestion 1998; 59:148–156CrossRefPubMedGoogle Scholar
  38. 38.
    Wastawski-Wende J, Kotchen JM, Anderson GL et al. Calcium plus Vitamin D Supplementation and the Risk of Colorectal Cancer. N Engl J Med 2006;354(16):684–696)CrossRefGoogle Scholar

Copyright information

© Hellenic Surgical Society 2010

Authors and Affiliations

  1. 1.Surgical ClinicMessologi General Hospital “Hatzikosta”MessologiGreece
  2. 2.Department of Nutrition and BiochemistryNational School of Public HealthAthensGreece

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