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Journal of Physiology and Biochemistry

, Volume 74, Issue 4, pp 591–601 | Cite as

The relationship between adiposopathy and glucose-insulin homeostasis is not affected by moderate-intensity aerobic training in healthy women with obesity

  • Andrée-Anne Clément
  • Eléonor Riesco
  • Sébastien Tessier
  • Michel Lacaille
  • Francine Pérusse
  • Mélanie Coté
  • Jean-Pierre Després
  • John Weisnagel
  • Jean Doré
  • Denis R. Joanisse
  • Pascale MauriègeEmail author
Original Article
  • 166 Downloads

Abstract

The contribution of adiposopathy to glucose-insulin homeostasis remains unclear. This longitudinal study examined the potential relationship between the adiponectin/leptin ratio (A/L, a marker of adiposopathy) and insulin resistance (IR: homeostasis model assessment (HOMA)), insulin sensitivity (IS: Matsuda), and insulin response to an oral glucose tolerance test before and after a 16-week walking program, in 29 physically inactive pre- and postmenopausal women with obesity (BMI, 29–35 kg/m2; age, 47–54 years). Anthropometry, body composition, VO2max, and fasting lipid-lipoprotein and inflammatory profiles were assessed. A/L was unchanged after training (p = 0.15), despite decreased leptin levels (p < 0.05). While the Matsuda index tended to increase (p = 0.07), HOMA decreased (p < 0.05) and fasting insulin was reduced (p < 0.01) but insulin area under the curve (AUC) remained unchanged (p = 0.18) after training. Body fatness and VO2max were improved (p < 0.05) while triacylglycerols increased and HDL-CHOL levels decreased after training (p < 0.05). At baseline, A/L was positively associated with VO2max, HDL-CHOL levels, and Matsuda (0.37 < ρ < 0.56; p < 0.05) but negatively with body fatness, HOMA, insulin AUC, IL-6, and hs-CRP levels (− 0.41 < ρ < − 0.66; p < 0.05). After training, associations with fitness, HOMA, and inflammation were lost. Multiple regression analysis revealed A/L as an independent predictor of IR and IS, before training (partial R2 = 0.10 and 0.22), although A/L did not predict the insulin AUC pre- or post-intervention. A significant correlation was found between training-induced changes to A/L and IS (r = 0.38; p < 0.05) but not with IR or insulin AUC. Although changes in the A/L ratio could not explain improvements to glucose-insulin homeostasis indices following training, a relationship with insulin sensitivity was revealed in healthy women with obesity.

Keywords

Adiponectin Leptin Insulin sensitivity Brisk walking Menopausal status 

Notes

Acknowledgments

The cooperation of the participants who participated to this walking program is greatly appreciated.

Thanks to Alexandra Andersen, Denise Christen, Katie Lacasse, Geneviève Ouellet, Renaud Turcotte-Sabourin, Guillaume Salamin, and Jean Tremblay for their very helpful assistance in the supervision of walking sessions as well as to Caroline Brière, dietetic technician, for her dedicated work on the 3-day dietary records. Special thanks to Valérie-Ève Julien, Marie-Christine Dubé, and Marie Tremblay for their precious help and implication in OGTT.

Funding information

This study was supported by the operating grant # MOP-77572 obtained from the Canadian Institutes of Health Research (PM) and from the Fondation du Centre de Recherche de l’Institut Universitaire de Cardiologie et Pneumologie de Québec (DRJ).

Compliance with ethical standards

The experimental design was approved by the Laval University Ethics Committee on Human Research for Medical Sciences, and all participants provided written informed consent.

Conflict of interest

The authors declare that they have no conflicts of interest.

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Copyright information

© University of Navarra 2018

Authors and Affiliations

  • Andrée-Anne Clément
    • 1
    • 2
  • Eléonor Riesco
    • 3
  • Sébastien Tessier
    • 4
  • Michel Lacaille
    • 1
    • 2
  • Francine Pérusse
    • 1
    • 2
  • Mélanie Coté
    • 2
  • Jean-Pierre Després
    • 1
    • 2
  • John Weisnagel
    • 5
    • 6
  • Jean Doré
    • 1
  • Denis R. Joanisse
    • 1
    • 2
  • Pascale Mauriège
    • 1
    • 2
    Email author
  1. 1.Department of Kinesiology, Faculty of MedicineLaval UniversityQuébecCanada
  2. 2.Québec Heart and Lung University Research CentreQuébecCanada
  3. 3.Faculty of Physical Activity Sciences, University of Sherbrooke, and Research Centre on AgingCIUSSS de l’Estrie – CHUSSherbrookeCanada
  4. 4.Institut National de Santé PubliqueQuébecCanada
  5. 5.Lipid Research CentreCentre Hospitalier de l’Université Laval (CHUL)QuébecCanada
  6. 6.Diabetes Research UnitCentre Hospitalier de l’Université Laval (CHUL)QuébecCanada

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