The “bioregulatory effect of exercise” on the innate/inflammatory responses
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The effects of exercise on the innate response are primarily mediated by the SNS (sympathetic nervous system) and/or the HPA (hypothalamic-pituitary-adrenal) axis and by stress proteins such as Hsp72. Regular exercise can induce immuno-neuroendocrine stabilization in persons with deregulated inflammatory and stress feedback by reducing the presence of stress hormones and inflammatory cytokines. Anti-inflammatory and “anti-stress” responses seem also to be induced (paradoxically, opposite to the effects in healthy persons) after sessions of exercise, being a promising strategy for treating certain inflammatory pathologies. Nevertheless, the biomedical side effects of exercise are also needed to be considered. This article defines the “Bioregulatory Effect of Exercise” to be one that reduces or prevents any excessive effect of inflammatory mediators and stimulates (or at least does not impair) the innate defences (i.e. chemotaxis, phagocytosis, and microbicidal activities) against pathogens. It also generates immunophysiological adaptations through an optimal balance between the pro- and the anti-inflammatory responses. These effects are mediated via immuno-neuroendocrine interactions. This review analyses concepts and conclusions related to how exercise affects the innate and/or inflammatory responses and discusses some paradoxical interpretations relevant for the practical use of exercise in treating infectious and inflammatory diseases. A potential role of exercise as hormesis strategy and the concept of exercise immunization are also discussed.
KeywordsExercise Stress Innate and inflammatory responses Bioregulatory effect Hormesis
I thank Dr R. A. Chatwin for his critical review of the English and Junta de Extremadura-FEDER (GR15041).
- 4.Bote ME, García JJ, Hinchado MD, Ortega E (2014) An exploratory study of the effect of regular aquatic exercise on the function of neutrophils from women with fibromyalgia: role of IL-8 and noradrenaline. Brain Behav Immun 51:576–581Google Scholar
- 5.Bote ME, Ortega E (2015) Regulation by exercise of the altered inflammatory status: response in fibromyalgia patients. Arch Med Deporte 32:136–143Google Scholar
- 12.Dhabhar FS and McEwen BS (2001) Bidirectional effects of stress and glucocorticoid hormones on immune function: possible explanations for paradoxical observations. In: Ader R, Felten D, Cohen N (eds) Psychoneuroimmunology, Academic Press, pp 301–337Google Scholar
- 19.Giraldo E, García JJ, Hinchado MD, Ortega E (2009) Exercise intensity-dependent changes in the inflammatory response in sedentary women: role of neuroendocrine parameters in the neutrophil phagocytic process and the pro-/anti-inflammatory cytokine balance. Neuroimmunomodulation 16:237–244CrossRefPubMedGoogle Scholar
- 23.Ji LL (2006) Oxidative stress and antioxidative defense: effects of aging and exercise. In: Alessio HM, Hagerman AE (eds), Oxidative Stress, Exercise, and Aging, Imperial College Press pp 85–108Google Scholar
- 38.Phillips MD, Flynn MG, McFarlin BK, Stewart LK, Ji H, Liu J, Timmerman KL, Kim JK (2001) Proinflammatory cytokines in response to acute and chronic exercise in women aged 65–89 years (abstract). Med Sci Sports Exer 33:S69Google Scholar
- 39.Ploeger HE, Takken T, de Greef MH, Timmons BW (2009) The effects of acute and chronic exercise on inflammatory markers in children and adults with a chronic inflammatory disease: a systematic review. Exer Immunol Rev 15:6–41Google Scholar
- 43.Teixeira de Lemos E, Pinto R, Oliveira J, Garrido P, Sereno J, Mascarenhas-Melo F, Páscoa-Pinheiro J, Texeira F, Reis F (2011) Differential effects of acute (extenuating) and chronic (training) exercise on inflammation and oxidative stress status in an animal model of type 2 diabetes mellitus. Mediators Inflamma 2011:253061. doi: 10.1155/2011/253061 CrossRefGoogle Scholar
- 44.Teixeira de Lemos E, Reis F, Baptista S, Pinto R, Sepodes B, Vala H, Rocha-Pereira P, Correia da Silva G, Teixeira N, Silva AS, Carvalho L, Teixeira F, Das UN (2009) Exercise training decrease proinflammatory profile in Zucker diabetic (type 2) fatty rats. Nutrition 25:330–339CrossRefPubMedGoogle Scholar
- 45.Walsh NP, Gleeson M, Shephard RJ, Gleeson M, Woods JA, Bishop NC, Fleshner M, Gree C, Pedersen BK, Hoffman-Goetz L, Rogers CJ, Northoff H, Abbasi A, Simon P (2011) Position statement. Part one: immune function and exercise. Exer Immunol Rev 17:6–63Google Scholar