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Journal of Physiology and Biochemistry

, Volume 71, Issue 4, pp 855–860 | Cite as

Association between genetic variants of the clock gene and obesity and sleep duration

  • Macarena Valladares
  • Ana María Obregón
  • Jean-Philippe Chaput
Mini Review

Abstract

Obesity is a multifactorial disease caused by the interaction of genetic and environmental factors related to lifestyle aspects. It has been shown that reduced sleep is associated with increased body mass index (BMI). Circadian Locomotor Output Cycles Kaput (CLOCK) gene variants have also been associated with obesity. The objective of this mini-review was to discuss the available literature related to CLOCK gene variants associated with adiposity and sleep duration in humans. In total, 16 articles complied with the terms of the search that reported CLOCK variants associated with sleep duration, energy intake, and BMI. Overall, six CLOCK single nucleotide polymorphisms (SNPs) have been associated with sleep duration, and three variants have been associated with energy intake variables. Overall, the most studied area has been the association of CLOCK gene with obesity; close to eight common variants have been associated with obesity. The most studied CLOCK SNP in different populations is rs1801260, and most of these populations correspond to European populations. Collectively, identifying at risk CLOCK genotypes is a new area of research that may help identify individuals who are more susceptible to overeating and gaining weight when exposed to short sleep durations.

Keywords

CLOCK polymorphism Obesity Sleep duration Eating behavior 

Notes

Acknowledgments

This work was supported by Fondecyt de Inicio 11130200.

References

  1. 1.
    Allebrandt KV, Teder-Laving M, Akyol M, Pichler I, Müller-Myhsok B, Pramstaller P et al (2010) CLOCK gene variants associate with sleep duration in two independent populations. Biol Psychiatry 67:1040–1047CrossRefPubMedGoogle Scholar
  2. 2.
    Bandín C, Martinez-Nicolas A, Ordovás JM, Ros Lucas JA, Castell P, Silvente T et al (2013) Differences in circadian rhythmicity in CLOCK 3111T/C genetic variants in moderate obese women as assessed by thermometry, actimetry and body position. Int J Obes (Lond) 37:1044–1150CrossRefGoogle Scholar
  3. 3.
    Cappuccio FP, D’Elia L, Strazzullo P, Miller MA (2010) Sleep duration and all-cause mortality: a systematic review and meta-analysis of prospective studies. Sleep 33:585–592PubMedCentralPubMedGoogle Scholar
  4. 4.
    Dashti HS, Follis JL, Smith CE, Tanaka T, Cade BE, Gottlieb DJ et al (2015) Habitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants. Am J Clin Nutr 101:135–143CrossRefPubMedGoogle Scholar
  5. 5.
    Dean E, Bloom A, Cirillo M, Hong Q, Jawl B, Jukes J, Nijjar M et al (2012) Association between habitual sleep duration and blood pressure and clinical implications: a systematic review. Blood Press 21:45–57CrossRefPubMedGoogle Scholar
  6. 6.
    Friedman JM (2000) Obesity in the new millennium. Nature 404:632–634PubMedGoogle Scholar
  7. 7.
    Froy O (2010) Metabolism and circadian rhythms—implications for obesity. Endocr Rev 31:1–24CrossRefPubMedGoogle Scholar
  8. 8.
    Garaulet M, Lee YC, Shen J, Parnell LD, Arnett DK, Tsai MY et al (2009) CLOCK genetic variation and metabolic syndrome risk: modulation by monounsaturated fatty acids. Am J Clin Nutr 90:1466–1475PubMedCentralCrossRefPubMedGoogle Scholar
  9. 9.
    Garaulet M, Lee YC, Shen J, Parnell LD, Arnett DK, Tsai MY et al (2010) Genetic variants in human CLOCK associate with total energy intake and cytokine sleep factors in overweight subjects (GOLDN population). Eur J Hum Genet 18:364–369PubMedCentralCrossRefPubMedGoogle Scholar
  10. 10.
    Garaulet M, Corbalán MD, Madrid JA, Morales E, Baraza JC, Lee YC et al (2010) CLOCK gene is implicated in weight reduction in obese patients participating in a dietary programme based on the Mediterranean diet. Int J Obes (Lond) 34:516–523CrossRefGoogle Scholar
  11. 11.
    Garaulet M, Sánchez-Moreno C, Smith CE, Lee YC, Nicolás F, Ordovás JM (2011) Ghrelin, sleep reduction and evening preference: relationships to CLOCK 3111 T/C SNP and weight loss. PLoS One 6:1–7CrossRefGoogle Scholar
  12. 12.
    Garaulet M, Tardido A, Lee YC, Smith CE, Parnell LD, Ordovás JM (2012) SIRT1 and CLOCK 3111T > C combined genotype is associated with evening preference and weight loss resistance in a behavioral therapy treatment for obesity. Int J Obes (Lond) 36:1436–1441CrossRefGoogle Scholar
  13. 13.
    Garcia-Rios A, Gomez-Delgado FJ, Garaulet M, Alcala-Diaz JF, Delgado-Lista FJ, Marin C (2014) Beneficial effect of CLOCK gene polymorphism rs1801260 in combination with low-fat diet on insulin metabolism in the patients with metabolic syndrome. Chronobiol Int 31:401–408CrossRefPubMedGoogle Scholar
  14. 14.
    Giovaninni NP, Fuly JT, Moraes LI, Coutinho TN, Trarbach EB, Jorge AA et al (2014) Study of the association between 3111T/C polymorphism of the CLOCK gene and the presence of overweight in schoolchildren. J Pediatr (Rio J) 90:500–505CrossRefGoogle Scholar
  15. 15.
    Gomez-Delgado F, Garcia-Rios A, Alcala-Diaz JF, Rangel-Zuñiga O, Delgado-Lista J, Yubero-Serrano EM et al. (2015) Chronic consumption of a low-fat diet improves cardiometabolic risk factors according to the CLOCK gene in patients with coronary heart disease. Mol Nutr Food Res:1–9Google Scholar
  16. 16.
    Guo X, Zheng L, Wang J, Zhang X, Zhang X, Li J, Sun Y (2013) Epidemiological evidence for the link between sleep duration and high blood pressure: a systematic review and meta-analysis. Sleep Med 14:324–332CrossRefPubMedGoogle Scholar
  17. 17.
    Iwase T, Kajimura N, Uchiyama M, Ebisawa T, Yoshimura K, Kamei Y et al (2002) Mutation screening of the human Clock gene in circadian rhythm sleep disorders. Psychiatry Res 109:121–128CrossRefPubMedGoogle Scholar
  18. 18.
    Kreier F, Kalsbeek A, Ruiter M, Yilmaz A, Romijn JA, Sauerwein HP et al (2003) Central nervous determination of food storage—a daily switch from conservation to expenditure: implications for the metabolic syndrome. Eur J Pharmacol 480:51–65CrossRefPubMedGoogle Scholar
  19. 19.
    Lane JM, Tare A, Cade BE, Chen TH, Punjabi NM, Gottlieb DJ et al (2013) Common variants in CLOCK are not associated with measures of sleep duration in people of European ancestry from the Sleep Heart Health Study. Biol Psychiatry 15:33–35CrossRefGoogle Scholar
  20. 20.
    Matricciani L, Olds T, Petkov J (2012) In search of lost sleep: secular trends in the sleep time of school-aged children and adolescents. Sleep Med Rev 16:203–211CrossRefPubMedGoogle Scholar
  21. 21.
    Mishima K, Tozawa T, Satoh K, Saitoh H, Mishima Y (2005) The 3111T/C polymorphism of hClock is associated with evening preference and delayed sleep timing in a Japanese population sample. Am J Med Genet B Neuropsychiatr Genet 133:101–104CrossRefGoogle Scholar
  22. 22.
    Monteleone P, Tortorella A, Docimo L, Maldonato MN, Canestrelli B, De Luca L, Maj M (2008) Investigation of 3111T/C polymorphism of the CLOCK gene in obese individuals with or without binge eating disorder: association with higher body mass index. Neurosci Lett 11:30–33CrossRefGoogle Scholar
  23. 23.
    Obregón AM, Amador P, Valladares M, Weisstaub G, Burrows R, Santos JL (2010) Melanocortin-3 receptor gene variants: association with childhood obesity and eating behavior in Chilean families. Nutrition 26:760–765CrossRefPubMedGoogle Scholar
  24. 24.
    Rankinen T, Bouchard C (2006) Genetics of food intake and eating behavior phenotypes in humans. Annu Rev Nutr 26:413–434CrossRefPubMedGoogle Scholar
  25. 25.
    Scott EM, Carter AM, Grant PJ (2008) Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man. Int J Obes (Lond) 32:658–662CrossRefGoogle Scholar
  26. 26.
    Sookoian S, Gemma C, Gianotti TF, Burgueño A, Castaño G, Pirola CJ (2008) Genetic variants of Clock transcription factor are associated with individual susceptibility to obesity. Am J Clin Nutr 87:1606–1615PubMedGoogle Scholar
  27. 27.
    Valladares M, Domínguez-Vásquez P, Obregón AM, Weisstaub G, Burrows R, Maiz A et al (2010) Melanocortin-4 receptor gene variants in Chilean families: association with childhood obesity and eating behavior. Nutr Neurosci 13:71–78CrossRefPubMedGoogle Scholar
  28. 28.
    Valladares M, Obregón AM, Weisstaub G, Burrows R, Patiño A, Ho-Urriola J et al (2015) Association between feeding behavior, and genetic polymorphism of leptin and its receptor in obese Chilean children. Nutr Hosp 31:1044–1051Google Scholar
  29. 29.
    WB&A Market Research: National Sleep Foundation. Sleep in America poll. Washington DC: National Sleep Foundation 2002. Available via DIALOG. http://www.sleepfoundation.org/article/sleep-america-polls/2002-adult-sleep-habits. Accessed 10 June 2015

Copyright information

© University of Navarra 2015

Authors and Affiliations

  1. 1.Unidad de Salud del Observatorio Regional de Paz y Seguridad (ORPAS)Universidad Bernardo O HigginsSantiagoChile
  2. 2.Carrera de Nutrición y DietéticaUniversidad San SebastianConcepcionChile
  3. 3.Healthy Active Living and Obesity Research GroupChildren’s Hospital of Eastern Ontario Research InstituteOttawaCanada

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