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Journal of Physiology and Biochemistry

, Volume 71, Issue 1, pp 79–88 | Cite as

Effects of exercise at individual anaerobic threshold and maximal fat oxidation intensities on plasma levels of nesfatin-1 and metabolic health biomarkers

  • Hamid Mohebbi
  • Maryam Nourshahi
  • Mansour Ghasemikaram
  • Saleh Safarimosavi
Original Paper

Abstract

Exercise is recognized as an effective method of weight management and short-term appetite regulation tool. The effect of different exercise intensities on appetite regulation hormones in healthy overweight participants has not been intensively studied. The aim of this study was to examine the influence of exercise at individual anaerobic threshold (IAT) and maximal fat oxidation (Fatmax) intensities on the nesfatin-1 response and metabolic health biomarkers in overweight men. Nine healthy overweight males (age, 23.1 ± 1.1 years) volunteered in this study in a counterbalanced order. Blood samples were obtained before, immediately after, and following the first 45 min of recovery for measuring plasma variables. There was significant decrease in plasma levels of nesfatin-1 and leptin after exercise at the IAT intensity which remained lower than baseline following 45 min of recovery. However, nesfatin-1 and leptin levels did not change significantly in any time courses of Fatmax intensity (P > 0.09). Plasma interleukin-6 (IL-6) concentration increased during exercise in both intensities (P < 0.05), whereas changes in free fatty acids (FFAs) and epinephrine concentrations were significant only at the IAT. In addition, a significant correlation was found among nesfatin-1 levels with insulin (r = 0.39, P < 0.05) and glucose (r = 0.41, P < 0.05) at basal and in response to exercise. These results indicate that IAT has a greater exercise-induced appetite regulation effect compared with Fatmax. Based on these data, the intensity of exercise may have an important role in changes of nesfatin-1, leptin, FFA, and epinephrine concentrations even though this was not the case for IL-6 and insulin resistance.

Keywords

Adipokine Cytokine Fatmax Insulin resistance Type of exercise 

Abbreviations

BMI

Body mass index

BP

Blood pressure

BPM

Beats per min

CV

Intra-assay coefficient of variation

CON

Control

EE

Energy expenditure

ES

Effect size

Fatmax

Maximal fat oxidation

FFA

Free fatty acid

HOMA-IR

Homeostasis model-estimated insulin resistance

HR

Heart rate

IAT

Individual anaerobic threshold

IL-6

Interleukin-6

IMTG

Intramuscular triacylglycerol

WHR

Waist-to-hip ratio

RER

Respiratory exchange ratio

VO2peak

Peak oxygen uptake

ΔPV

Changes in plasma volume

Notes

Acknowledgments

The authors would like to thank the dedicated group of participants.

Funding

This research was supported by a research fund from Guilan University.

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Copyright information

© University of Navarra 2015

Authors and Affiliations

  • Hamid Mohebbi
    • 1
  • Maryam Nourshahi
    • 2
  • Mansour Ghasemikaram
    • 2
  • Saleh Safarimosavi
    • 1
  1. 1.Department of Exercise Physiology, Faculty of Sport ScienceUniversity of GuilanRashtIran
  2. 2.Department of Exercise Physiology, Faculty of Sport ScienceUniversity of Shahid BeheshtiTehranIran

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