Journal of Physiology and Biochemistry

, Volume 70, Issue 2, pp 569–581 | Cite as

Glucose and glutamine metabolism control by APC and SCF during the G1-to-S phase transition of the cell cycle

  • Irving Omar Estévez-García
  • Verónica Cordoba-Gonzalez
  • Eleazar Lara-Padilla
  • Abel Fuentes-Toledo
  • Ramcés Falfán-Valencia
  • Rafael Campos-Rodríguez
  • Edgar Abarca-RojanoEmail author
Mini Review


Recent studies have given us a clue as to how modulations of both metabolic pathways and cyclins by the ubiquitin system influence cell cycle progression. Among these metabolic modulations, an aerobic glycolysis and glutaminolysis represent an initial step for metabolic machinery adaptation. The enzymes 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) and glutaminase-1 (GLS1) maintain a high abundance in glycolytic intermediates (for synthesis of non-essential amino acids, the use of ribose for the synthesis of nucleotides and hexosamine biosynthesis), as well as tricarboxylic acid cycle intermediates (replenishing the loss of mitochondrial citrate), respectively. On the one hand, regulation of these key metabolic enzymes by ubiquitin ligases anaphase-promoting complex/cyclosome (APC/C) and Skp1/cullin/F-box (SCF) has revealed the importance of anaplerosis by both glycolysis and glutaminolysis to overcome the restriction point of the G1 phase by maintaining high levels of glycolytic and glutaminolytic intermediates. On the other hand, only glutaminolytic intermediates are necessary to drive cell growth through the S and G2 phases of the cell cycle. It is interesting to appreciate how this reorganization of the metabolic machinery, which has been observed beyond cellular proliferation, is a crucial determinant of a cell’s decision to proliferate. Here, we explore a unifying view of interactions between the ubiquitin system, metabolic activity, and cyclin-dependent kinase complexes activity during the cell cycle.


Anaphase-promoting complex/cyclosome Skp1/cullin/F-box Cell cycle Aerobic glycolysis Glutaminolysis Anaplerosis 



The present work was performed with the support of “Instituto Politécnico Nacional” through “Programa Institucional para la Formación de Investigadores.”


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Copyright information

© University of Navarra 2014

Authors and Affiliations

  • Irving Omar Estévez-García
    • 1
  • Verónica Cordoba-Gonzalez
    • 1
  • Eleazar Lara-Padilla
    • 1
  • Abel Fuentes-Toledo
    • 1
  • Ramcés Falfán-Valencia
    • 2
  • Rafael Campos-Rodríguez
    • 1
  • Edgar Abarca-Rojano
    • 1
    • 3
    Email author
  1. 1.Instituto Politecnico Nacional, Escuela Superior de Medicina, Seccion de Estudios de Posgrado e InvestigacionMéxico CityMexico
  2. 2.Laboratorio HLAInstituto Nacional de Enfermedades Respiratorias Ismael Cosio VillegasMéxico CityMexico
  3. 3.Laboratorio de Respiracion CelularInstituto Politecnico Nacional, Escuela Superior de Medicina, Seccion de Estudios de Posgrado e InvestigacionMexico D.F.Mexico

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