Journal of Physiology and Biochemistry

, Volume 70, Issue 2, pp 639–646 | Cite as

Resveratrol does not increase body fat loss induced by energy restriction

  • Goiuri Alberdi
  • M. Teresa Macarulla
  • María P. Portillo
  • Víctor M. Rodríguez
Original Paper


Resveratrol (RSV) is known to have an antiobesogenic effect because it mimics energy restriction. However, hardly any evidence exists concerning the combined effects of RSV and energy restriction on body fat reduction. So, the aim of the present study was to determine whether RSV increases body fat reduction induced by energy restriction. Male Wistar rats were fed a high-fat, high-sucrose diet for 6 weeks to obtain a diet-induced obesity model. Then they were submitted to a mild energy restriction (25 %) without or with RSV supplementation (30 mg/kg body weight/day) for 2 weeks. Final body weight, subcutaneous and intra-abdominal white adipose tissues weights, Adipose Index, and serum triacylglycerol, cholesterol, glucose, and insulin were assessed. Lipoprotein lipase (LPL), fatty acid synthase (FAS), and acetyl coenzyme A carboxylase (ACC) activities, as well as their genetic expressions, were measured in white adipose tissue. Final body weight, white adipose tissue weights, Adipose Index, and serum triacylglycerol, cholesterol, and insulin were reduced in both groups, but no differences were found among them. FAS, ACC, and LPL activities and expressions were also similar in both groups. These results suggest a lack of any adjuvant effect of RSV on energy restriction for obesity treatment purposes.


Resveratrol Energy restriction Adipose tissue Lipogenesis 


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Copyright information

© University of Navarra 2014

Authors and Affiliations

  • Goiuri Alberdi
    • 1
    • 2
  • M. Teresa Macarulla
    • 1
    • 2
    • 3
  • María P. Portillo
    • 1
    • 2
  • Víctor M. Rodríguez
    • 1
    • 2
  1. 1.Nutrition and Obesity Group, Department of Nutrition and Food Sciences and Research Institute Lucio LascarayUniversity of the Basque Country (UPV/EHU)VitoriaSpain
  2. 2.CIBERobn Physiopathology of Obesity and NutritionInstitute of Health Carlos III (ISCIII)MadridSpain
  3. 3.Departamento de Nutrición y Bromatología, Facultad de FarmaciaVitoriaSpain

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