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Journal of Physiology and Biochemistry

, Volume 69, Issue 4, pp 957–961 | Cite as

Nephroprotective action of sirtuin 1 (SIRT1)

  • Dorota Polak-Jonkisz
  • Krystyna Laszki-Szcząchor
  • Leopold Rehan
  • Witold Pilecki
  • Henryk Filipowski
  • Małgorzata Sobieszczańska
Mini Review

Abstract

Sirtuins, silent information regulator 2 (Sir 2) proteins, belong to the family of NAD+-dependent enzymes with deacetylase or mono-ADP-ribosyltransferase activity. These enzymes are responsible for processes of DNA repair or recombination, chromosomal stability and gene transcription. In mammals, sirtuins occur in seven varieties, from 1 to 7 (SIRT1–SIRT7), differing among themselves with location. SIRT1, the best known variety, exerts its effects on proteins via NAD+ coenzymes, being thus associated with cellular energetic metabolism and the ‘red–ox’ state. Its deficits are, among others, concomitant with stressful situations and associated with pathophysiologies of many medical conditions, including diabetes mellitus, cardiovascular diseases, neurodegenerative syndromes and kidney diseases. In kidney disorders, it promotes (stimulates) the survival of cells in an affected kidney by modulating their responses to various stress stimuli, takes part in arterial blood pressure control, protects against cellular apoptosis in renal tubules by catalase induction and triggers autophagy. More and more available in vitro and in vivo data indicate SIRT1 activity to be oriented, among others, towards nephroprotection. Thus, SIRT1 may become a novel element in the therapy of age-related renal diseases, including diabetic nephropathy.

Keywords

Sirtuins Sirtuin 1 SIRT1 Nephroprotection 

Abbreviations

ACE

Angiotensin-converting-enzyme

Atg5

Autophagy protein 5

Atg7

Autophagy protein 7

ATP

Adenosine-5'-triphosphate

COX2

Cyclooxygenase-II enzyme

CR

Caloric restriction

DNA

Deoxyribonucleic acid

Dot1

Disruptor of telomeric silencing-1

ENaC

Epithelial sodium channel

ERK

Extracellular signal-regulated kinases

FOXO3

Forkhead box O3

FXR

farnesoid X receptor

HIF-2a

hypoxia-inducible factor

Ku70

Protein that, in humans, is encoded by the XRCC6 gene

LC3

protein light chain 3

LXR

liver X receptor

Lys310

lysine 310

NAD+

Nicotinamide adenine dinucleotide

NAM

Generating nicotinamide

NF-κB

Nuclear factor kappa B

NO

Nitrogen oxide

PGE2

prostaglandin E2

AT1R

angiotensin II receptor, type 1

SIRT

Silent information regulator

Smad3

Mothers against decapentaplegic homolog 3

SREBP

sterol regulatory element binding proteins

TGF-β1

Transforming growth factor beta

UCP2

uncoupling protein 2

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Copyright information

© University of Navarra 2013

Authors and Affiliations

  • Dorota Polak-Jonkisz
    • 1
  • Krystyna Laszki-Szcząchor
    • 2
  • Leopold Rehan
    • 3
  • Witold Pilecki
    • 2
  • Henryk Filipowski
    • 2
  • Małgorzata Sobieszczańska
    • 2
  1. 1.Department of Paediatric NephrologyWroclaw Medical UniversityWroclawPoland
  2. 2.Department of PathophysiologyWroclaw Medical UniversityWrocławPoland
  3. 3.Clinical Centre of Wroclaw Medical UniversityWroclawPoland

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