Journal of Physiology and Biochemistry

, Volume 69, Issue 4, pp 779–783 | Cite as

Hypoglycemic and hepatoprotective activity of Rosmarinus officinalis extract in diabetic rats

  • Kholoud S. RamadanEmail author
  • Olfat A. Khalil
  • Enas N. Danial
  • Hanan S. Alnahdi
  • Najla O. Ayaz
Original Paper


The present study examined the effect of water extract (200 mg/kg body weight) of Rosmarinus officinalis L. in streptozotocin (STZ)-induced diabetic rats for 21 days. The hepatoprotective effects were investigated in the liver tissues sections. There was a significant increase in serum liver biochemical parameters (aspartate aminotransferase, alanine transaminase, and alkaline phosphatase), accompanied by a significant decrease in the level of total protein and albumin in the STZ-induced rats when compared with that of the normal group. The high-dose treatment group (200 mg/kg body wt) significantly restored the elevated liver function enzymes near to normal. This study revealed that rosemary extracts exerted a hepatoprotective effect. The results indicate that the extract exhibits the protective effect on tissues and prove its potentials as an antidiabetic agent.


Diabetes Hypoglycemia Hepatoprotection Streptozotocin Rosmarinus officinalis 


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Copyright information

© University of Navarra 2013

Authors and Affiliations

  • Kholoud S. Ramadan
    • 1
    • 2
    Email author
  • Olfat A. Khalil
    • 3
  • Enas N. Danial
    • 1
    • 4
  • Hanan S. Alnahdi
    • 1
  • Najla O. Ayaz
    • 1
  1. 1.Department of Biochemistry, Faculty of Girls ScienceKing Abdulaziz UniversityJeddahSaudi Arabia
  2. 2.Department of Biochemistry, Faculty of ScienceAin Shams UniversityCairoEgypt
  3. 3.Clinical Biochemistry Department, Faculty of MedicineEl-Azher UniversityCairoEgypt
  4. 4.Chemistry of Natural and Microbial Products DepartmentNational Research CenterCairoEgypt

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