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Journal of Physiology and Biochemistry

, Volume 69, Issue 4, pp 677–686 | Cite as

Curcumin prevents liver fat accumulation and serum fetuin-A increase in rats fed a high-fat diet

  • Yildiz Öner-İyidoğanEmail author
  • Hikmet Koçak
  • Muhammed Seyidhanoğlu
  • Figen Gürdöl
  • Ahmet Gülçubuk
  • Funda Yildirim
  • Aydin Çevik
  • Müjdat Uysal
Original Paper

Abstract

Fetuin-A is synthesized in the liver and is secreted into the bloodstream. Clinical studies suggest involvement of fetuin-A in metabolic disorders such as visceral obesity, insulin resistance, diabetes, and fatty liver. Curcumin is extracted from the rhizome Curcuma longa and has been shown to possess potent antioxidant, anticarcinogenic, anti-inflammatory, and hypoglycemic properties. In this study, we investigated the effect of curcumin treatment on serum fetuin-A levels as well as hepatic lipids and prooxidant–antioxidant status in rats fed a high-fat diet (HFD). Male Sprague–Dawley rats were divided into six groups. Group 1 was fed control diet (10 % of total calories from fat). Groups 2 and 3 were given curcumin (100 and 400 mg/kg bw/day, respectively ) by gavage for 8 weeks and were fed control diet. Group 4 was fed with HFD (60 % of total calories from fat). Groups 5 and 6 received HFD together with the two doses of curcumin, respectively. Curcumin treatment appeared to be effective in reducing liver triglycerides and serum fetuin-A levels. These findings suggest that the reduction of fetuin-A may contribute to the beneficial effects of curcumin in the pathogenesis of obesity.

Keywords

Obesity Curcumin Fetuin-A Fatty liver High-fat diet 

Notes

Acknowledgments

This work was supported by the Research Fund of Istanbul University. Project number 8244.

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Copyright information

© University of Navarra 2013

Authors and Affiliations

  • Yildiz Öner-İyidoğan
    • 1
    Email author
  • Hikmet Koçak
    • 2
  • Muhammed Seyidhanoğlu
    • 1
  • Figen Gürdöl
    • 1
  • Ahmet Gülçubuk
    • 3
  • Funda Yildirim
    • 3
  • Aydin Çevik
    • 4
  • Müjdat Uysal
    • 1
  1. 1.Department of Biochemistry, Istanbul Faculty of MedicineIstanbul UniversityIstanbulTurkey
  2. 2.Department of Biochemistry, Faculty of MedicineIstanbul Bilim UniversityIstanbulTurkey
  3. 3.Department of Pathology, Faculty of Veterinary MedicineIstanbul UniversityIstanbulTurkey
  4. 4.Department of Laboratory Animal Biology and Applied Biomedical Techniques, Institute for Experimental Research and Applied Medical ResearchIstanbul UniversityIstanbulTurkey

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