Journal of Physiology and Biochemistry

, Volume 68, Issue 4, pp 611–618

Regulatory long non-coding RNA and its functions

  • Yong Huang
  • Ning Liu
  • Jian Ping Wang
  • Yu Qin Wang
  • Xue Li Yu
  • Zhan Bin Wang
  • Xiang Chao Cheng
  • Quan Zou
Mini Review

Abstract

The discovery of large numbers of long non-coding RNAs (lncRNAs) has been driven by genome-wide transcriptional analyses. Compared to small ncRNAs, lncRNAs have been shown to harbor biological activities, but the functions of the great majority of lncRNAs are not known. There is growing evidence that lncRNAs can regulate gene expression at epigenetic, transcription, and post-transcription levels and widely take part in various physiological and pathological processes, such as participating in cell development, immunity, oncogenesis, clinical disease processes, etc. Here, the current research efforts on the function of lncRNA in recent years were summarized.

Keywords

lncRNAs Gene expression Epigenetic Disease Cancer 

Copyright information

© University of Navarra 2012

Authors and Affiliations

  • Yong Huang
    • 1
  • Ning Liu
    • 1
  • Jian Ping Wang
    • 1
  • Yu Qin Wang
    • 1
  • Xue Li Yu
    • 1
  • Zhan Bin Wang
    • 1
  • Xiang Chao Cheng
    • 1
  • Quan Zou
    • 2
  1. 1.Animal Science and Technology CollegeHe Nan University of Science and TechnologyLuoyang CityPeople’s Republic of China
  2. 2.School of Information Science and TechnologyXiamen UniversityXiamen CityPeople’s Republic of China

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