Experimental Aneurysmal Subarachnoid Hemorrhage: Tiding Over
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Aneurysmal subarachnoid hemorrhage (aSAH) is a type of hemorrhagic stroke, which is associated with significant morbidity, and a case fatality of nearly 50% [6, 13, 17, 18]. Early brain injury (EBI) and delayed cerebral ischemia (DCI) are the two main determinants for functional outcome after aSAH. EBI refers to direct mechanical damage to the brain tissue and early pathophysiological changes, including increased intracranial pressure (ICP) and reduced cerebral perfusion. DCI describes a complex of reaction occurring thereafter . Various mechanisms contribute to DCI, including angiographic cerebral vasospasms, microvascular spasm, microthrombosis, cortical spreading depolarization, failure of cerebral autoregulation, and inflammatory responses . The individual importance of each of these pathomechanisms remains to be elucidated and it has been suggested that the etiology of EBI and DCI are linked. However, a unifying theory of these pathophysiological changes has...
We thank Christiane von Saß for careful reading of the manuscript.
This study is supported by MKMD grants from The Netherlands Organization for Health Research and Development (ZonMw Grand Numbers 114024130 and 114024137).
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflict of interest.
This article does not contain any studies with human participants or animals performed by any of the authors.
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