Translational Stroke Research

, Volume 11, Issue 1, pp 1–3 | Cite as

Experimental Aneurysmal Subarachnoid Hemorrhage: Tiding Over

  • Marcel A. Kamp
  • Hans-Jakob Steiger
  • Jasper Hans van LieshoutEmail author
Letter to the Editor

Dear Editor,

Aneurysmal subarachnoid hemorrhage (aSAH) is a type of hemorrhagic stroke, which is associated with significant morbidity, and a case fatality of nearly 50% [6, 13, 17, 18]. Early brain injury (EBI) and delayed cerebral ischemia (DCI) are the two main determinants for functional outcome after aSAH. EBI refers to direct mechanical damage to the brain tissue and early pathophysiological changes, including increased intracranial pressure (ICP) and reduced cerebral perfusion. DCI describes a complex of reaction occurring thereafter [20]. Various mechanisms contribute to DCI, including angiographic cerebral vasospasms, microvascular spasm, microthrombosis, cortical spreading depolarization, failure of cerebral autoregulation, and inflammatory responses [20]. The individual importance of each of these pathomechanisms remains to be elucidated and it has been suggested that the etiology of EBI and DCI are linked. However, a unifying theory of these pathophysiological changes has...



We thank Christiane von Saß for careful reading of the manuscript.


This study is supported by MKMD grants from The Netherlands Organization for Health Research and Development (ZonMw Grand Numbers 114024130 and 114024137).

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

This article does not contain any studies with human participants or animals performed by any of the authors.


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Neurosurgery, Medical FacultyHeinrich-Heine-University DüsseldorfDüsseldorfGermany
  2. 2.Department of NeurosurgeryRadboudumc Medical CenterNijmegenThe Netherlands

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