Cell Therapy in Stroke—Cautious Steps Towards a Clinical Treatment

Review

Abstract

In the future, stroke patients may receive stem cell therapy as this has the potential to restore lost functions. However, the development of clinically deliverable therapy has been slower and more challenging than expected. Despite recommendations by STAIR and STEPS consortiums, there remain flaws in experimental studies such as lack of animals with comorbidities, inconsistent approaches to experimental design, and concurrent rehabilitation that might lead to a bias towards positive results. Clinical studies have typically been small, lacking control groups as well as often without clear biological hypotheses to guide patient selection. Furthermore, they have used a wide range of cell types, doses, and delivery methods, and outcome measures. Although some ongoing and recent trial programs offer hints that these obstacles are now being tackled, the Horizon2020 funded RESSTORE trial will be given as an example of inconsistent regulatory requirements and challenges in harmonized cell production, logistic, and clinical criteria in an international multicenter study. The PISCES trials highlight the complex issues around intracerebral cell transplantation. Therefore, a better understanding of translational challenges is expected to pave the way to more successful help for stroke patients.

Keywords

Cell therapy Cerebrovascular diseases Experimental studies Clinical trials Translation 

Notes

Compliance with Ethical Standards

Conflict of Interest

Dr. Keith Muir is chief Investigator for PISCES 1 and PISCES 2 trials, funded by ReNeuron Ltd. He participated in advisory boards for ReNeuron. No other authors have a conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2017

Authors and Affiliations

  1. 1.Stroke Unit, Neurology DepartmentGrenoble HospitalGrenobleFrance
  2. 2.Grenoble Institute of Neurosciences, Inserm U1216Université Grenoble AlpesGrenobleFrance
  3. 3.Institute of Neuroscience & Psychology, University of GlasgowUniversity of GlasgowGlasgowUK
  4. 4.Queen Elizabeth University HospitalGlasgowUK
  5. 5.Department of NeurologyUniversity of Eastern FinlandKuopioFinland
  6. 6.NeuroCenterKuopio University HospitalKuopioFinland

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