Translational Stroke Research

, Volume 7, Issue 5, pp 439–445 | Cite as

Association between Leukoaraiosis and Poor Outcome is not due to Reperfusion Inefficiency after Intravenous Thrombolysis

  • Genlong Zhong
  • Shenqiang Yan
  • Sheng Zhang
  • Qingmeng Chen
  • Yangxiao Lai
  • Min LouEmail author
Original Article


Leukoaraiosis (LA) is associated with structural and functional cerebrovascular impairment, which may compromise the capacity of ischemic tissue to maximize reperfusion after intravenous thrombolysis (IVT). We aimed to determine whether severe LA is correlated with reperfusion inefficiency, which contributes to infarct growth and poor functional outcome. We analyzed data from our consecutive acute ischemic stroke (AIS) patients who had acquired baseline and 24-h follow-up diffusion- and perfusion-weighted imaging. Reperfusion was defined as reduction of ≥70 % of hypoperfusion lesion at 24 h from baseline. Severe LA was defined as Fazekas score 2 or 3 on FLAIR images. We investigated the relationship between severity of LA and reperfusion status. Multivariate statistical analysis was carried out for modeling the independent predictors of reperfusion, infarct growth, and functional outcome. Finally, 79 patients were included, among them 30 (37.97 %) had severe LA. Reperfusion was observed in 41 (51.89 %) patients, the proportion of reperfusion was very similar in patients with and without severe LA (53.33 vs 51.02 %, p = 1.000). Large artery occlusion was the only independent unfavorable predictor for reperfusion (OR = 0.202, 95 % confidence interval, 0.060–0.673; p = 0.014). Multiple linear regression analysis revealed that severe LA was independently associated with infarct growth (standardized coefficients = 0.191, p = 0.040). Severe LA was also an independent predictor of poor outcome (mRS ≥ 3) (OR = 4.004, 95 % confidence interval, 1.267–12.656, p = 0.018) after adjusting for reperfusion and baseline severity of stroke. Severe LA was associated with infarct growth and poor outcome independent of reperfusion status, which may expand the notion that LA contributes the intrinsic vulnerability of brain tissue to acute ischemic insults. The burden of LA may not serve as an imaging indicator of reperfusion inefficiency after IVT for AIS patients.


Leukoaraiosis Ischemic stroke Reperfusion Magnetic resonance imaging Thrombolysis Prognosis 


Compliance with Ethical Standards

Compliance with Ethics Requirements

The study procedures were in accordance with the Helsinki Declaration of 1975. Informed consent was obtained from all individual participants included in the study. The protocol of this study had been approved by the human ethics committee of a local hospital.

Conflict of Interest

The authors declare that they have no conflicts of interest.

Supplementary material

12975_2016_473_MOESM1_ESM.doc (38 kb)
ESM 1 (DOC 37.5 KB)
12975_2016_473_MOESM2_ESM.doc (50 kb)
ESM 2 (DOC 50.5 KB)


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Genlong Zhong
    • 1
  • Shenqiang Yan
    • 1
  • Sheng Zhang
    • 1
  • Qingmeng Chen
    • 1
  • Yangxiao Lai
    • 1
  • Min Lou
    • 1
    Email author
  1. 1.Department of NeurologyThe 2nd Affiliated Hospital of Zhejiang University, School of MedicineHangzhouChina

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