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Translational Stroke Research

, Volume 7, Issue 3, pp 186–191 | Cite as

Systolic Blood Pressure Variability is Associated with Severe Hemorrhagic Transformation in the Early Stage After Thrombolysis

  • Keqin Liu
  • Shenqiang Yan
  • Sheng Zhang
  • Yang Guo
  • Min LouEmail author
Original Article

Abstract

The present study investigates the association between hour-to-hour blood pressure (BP) variability and severe hemorrhagic transformation (HT) after intravenous thrombolysis (IVT) during hyperacute stage. We analyzed hour-to-hour BP measurement within 24 h after IVT in patients with acute ischemic stroke. We calculated the maximum, minimum, and average (mean) of 24-h BP values, and BP variability profiles including standard deviation (SD), average squared difference between successive measurements (SV), average squared difference between rise and drop successive measurements (SV rise and SV drop), and maximum of SV rise and SV drop (SVrisemax and SVdropmax) after quartering 0-to-24 h BP course. HT was classified as hemorrhagic infarction (HI) or parenchymal hematoma (PH). Symptomatic intracerebral hemorrhage (sICH) was defined as HT with worsening of the National Institute of Health Stroke Scale score by ≥4 points or leading to death. Severe HT was defined as either PH or sICH. Totally, 461 patients were included. We observed HT in 142 (30.8 %), PH in 43 (9.3 %), and sICH in 12 (2.6 %) patients. Binary logistic regression indicated that SBPSD and SBPSV within the first 24 h were associated with sICH (OR, 4.538; 95 % CI, 1.834–11.230; p = 0.001 and OR, 6.117; 95 % CI, 2.000–18.711; p = 0.002) and PH (OR, 2.146; 95 % CI, 1.106–4.165; p = 0.024 and OR, 2.202; 95 % CI, 1.046–4.633; p = 0.038). For the SBP SV parameters among four periods of the initial 24 h, only SV, SVrise, and SVrisemax during the first 6 h were significantly associated with sICH (OR, 2.785; 95 % CI, 1.294–5.994; p = 0.009; OR, 1.825; 95 % CI, 1.110–3.002; p = 0.018 and OR, 1.495; 95 % CI, 1.039–2.149; p = 0.030) and PH (OR, 2.088; 95 % CI, 1.287–3.387; p = 0.003; OR, 1.501; 95 % CI, 1.044–2.156; p = 0.028 and OR, 1.334; 95 % CI, 1.023–1.739; p = 0.033). High systolic BP variability during the first 6 h after IVT was related with severe HTs, which highlights the potential predictability to severe HTs.

Keywords

Acute ischemic stroke Thrombolysis Blood pressure Hemorrhagic transformation 

Notes

Acknowledgments

This work was supported by the Science Technology Department of Zhejiang Province (2013C03043-3) and the National Natural Science Foundation of China (81171095 and 81471170).

Compliance with Ethical Standards

Compliance with Ethics Requirements

The study procedures were in accordance with the Helsinki Declaration of 1975. All subjects (or their carers where appropriate) conducting the research project in this manuscript gave written informed consent, and the study was supported by the local ethics committee.

Conflicts of Interest

None.

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Keqin Liu
    • 1
    • 2
  • Shenqiang Yan
    • 1
  • Sheng Zhang
    • 1
  • Yang Guo
    • 1
  • Min Lou
    • 1
    Email author
  1. 1.Department of Neurology, School of MedicineThe 2nd Affiliated Hospital of Zhejiang UniversityHangzhouChina
  2. 2.Department of NeurologyHangzhou First People’s HospitalHangzhouChina

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