Cerebral Aneurysms: Formation, Progression, and Developmental Chronology
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The prevalence of unruptured intracranial aneurysms (UIAs) in the general population is up to 3 %. Existing epidemiological data suggests that only a small fraction of UIAs progress towards rupture over the lifetime of an individual, but the surrogates for subsequent rupture and the natural history of UIAs are discussed very controversially at present. In case of rupture of an UIA, the case fatality is up to 50 %, which therefore continues to stimulate interest in the pathogenesis of cerebral aneurysm formation and progression. Actual data on the chronological development of cerebral aneurysm has been especially difficult to obtain and, until recently, the existing knowledge in this respect is mainly derived from animal or mathematical models or short-term observational studies. Here, we review the current data on cerebral aneurysm formation and progression as well as a novel approach to investigate the developmental chronology of cerebral aneurysms.
KeywordsIntracranial aneurysms Aneurysm progression Aneurysm formation Developmental chronology
NE and RLM receive grant support from the Physicians Services Incorporated Foundation. RLM receives grant support from the Brain Aneurysm Foundation, Canadian Institutes of Health Research, and the Heart and Stroke Foundation of Ontario. RLM is a consultant for Actelion Pharmaceuticals and Chief Scientific Officer of Edge Therapeutics, Inc. NE, DH, and RLM are scientific advisors/officers for Edge Therapeutics, Inc.
Support was also provided by NIH/NIGMS 8P41GM103483. This work was performed in part under the auspices of the US Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.
Conflict of Interest
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