Introduction of a Rabbit Carotid Artery Model for Sonothrombolysis Research
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- Hölscher, T., Fisher, D.J., Ahadi, G. et al. Transl. Stroke Res. (2012) 3: 397. doi:10.1007/s12975-012-0194-5
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The goal of this study was to develop an in vivo sonothrombolysis model for stroke research. The rabbit carotid artery has average vessel diameters similar to human M1/M2 segments and allows generation of a thrombotic occlusion using various kinds of thrombus material as well as thrombus placement under visual control. It further allows real-time monitoring of flow and clot mechanics during the sonothrombolysis procedure using high-frequency diagnostic ultrasound. In the present study, the model will be introduced and first results to show feasibility using diagnostic as well as high-intensity focused ultrasound will be presented.