Translational Stroke Research

, Volume 3, Issue 3, pp 397–407

Introduction of a Rabbit Carotid Artery Model for Sonothrombolysis Research

  • Thilo Hölscher
  • David J. Fisher
  • Golnaz Ahadi
  • Arne Voie
Protocols

DOI: 10.1007/s12975-012-0194-5

Cite this article as:
Hölscher, T., Fisher, D.J., Ahadi, G. et al. Transl. Stroke Res. (2012) 3: 397. doi:10.1007/s12975-012-0194-5

Abstract

The goal of this study was to develop an in vivo sonothrombolysis model for stroke research. The rabbit carotid artery has average vessel diameters similar to human M1/M2 segments and allows generation of a thrombotic occlusion using various kinds of thrombus material as well as thrombus placement under visual control. It further allows real-time monitoring of flow and clot mechanics during the sonothrombolysis procedure using high-frequency diagnostic ultrasound. In the present study, the model will be introduced and first results to show feasibility using diagnostic as well as high-intensity focused ultrasound will be presented.

Keywords

Transcranial Rabbit Carotid artery High-intensity focused ultrasound Sonothrombolysis Stroke 

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Thilo Hölscher
    • 1
    • 2
  • David J. Fisher
    • 1
  • Golnaz Ahadi
    • 1
  • Arne Voie
    • 1
  1. 1.Brain Ultrasound Research Laboratory (BURL), Department of RadiologyUniversity of California San DiegoSan DiegoUSA
  2. 2.Department of NeurosciencesUniversity of California San DiegoSan DiegoUSA

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