Cardiovascular Intervention and Therapeutics

, Volume 28, Issue 3, pp 242–249

Use of Thrombolysis in Myocardial Infarction Risk Score to predict bleeding complications in patients with unstable angina and non-ST elevation myocardial infarction undergoing percutaneous coronary intervention

  • Yohei Numasawa
  • Shun Kohsaka
  • Hiroaki Miyata
  • Akio Kawamura
  • Shigetaka Noma
  • Masahiro Suzuki
  • Susumu Nakagawa
  • Yukihiko Momiyama
  • Toshiyuki Takahashi
  • Yuji Sato
  • Keiichi Fukuda
Original Article

Abstract

Thrombolysis in myocardial infarction (TIMI) is a prognostic score developed for managing the high risk of cardiac events immediately after unstable angina and non-ST elevation myocardial infarction (UA/NSTEMI). In Asian populations that have a higher rate of bleeding complications, data about TIMI score are lacking. Using a Japanese multicenter registry, we investigated the impact of utilizing TIMI score in UA/NSTEMI patients, focusing on bleeding complications. The TIMI score was calculated for 587 patients who underwent percutaneous coronary intervention (PCI) for UA/NSTEMI (2008–2010). They were classified into low-risk (TIMI score 0–2, N = 268, 45.6 %), intermediate-risk (TIMI score 3–4, N = 264, 45.0 %) and high-risk (TIMI score 5–7, N = 55, 9.4 %) groups; patient characteristics for each group were statistically analyzed. The patients in the higher TIMI score group were older (p < 0.001), had lower GFR (p = 0.021) and hemoglobin level after PCI (p < 0.001), and severe coronary disease pattern (p = 0.014 and p = 0.023, respectively, for left main and three-vessel disease). The TIMI score was significantly associated with requirement of blood transfusion (low-risk, moderate-risk, and high-risk groups: 1.1, 4.2, and 7.3 %, respectively; p = 0.021), and the incidence of access site bleeding (1.1, 2.7, and 5.5 %, p = 0.112). The TIMI score might aid in subjectively quantifying the risk of in-hospital complication rates such as access site bleeding.

Keywords

TIMI score Percutaneous coronary intervention Coronary artery disease 

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Copyright information

© Japanese Association of Cardiovascular Intervention and Therapeutics 2013

Authors and Affiliations

  • Yohei Numasawa
    • 1
  • Shun Kohsaka
    • 2
  • Hiroaki Miyata
    • 3
  • Akio Kawamura
    • 2
  • Shigetaka Noma
    • 4
  • Masahiro Suzuki
    • 5
  • Susumu Nakagawa
    • 6
  • Yukihiko Momiyama
    • 7
  • Toshiyuki Takahashi
    • 1
  • Yuji Sato
    • 8
  • Keiichi Fukuda
    • 2
  1. 1.Department of CardiologyAshikaga Red Cross HospitalAshikaga-shiJapan
  2. 2.Department of CardiologyKeio University School of MedicineTokyoJapan
  3. 3.University of Tokyo, Healthcare Quality AssessmentTokyoJapan
  4. 4.Department of CardiologySaiseikai Utsunomiya HospitalTochigiJapan
  5. 5.Department of CardiologyNational Hospital Organization, Saitama National HospitalSaitamaJapan
  6. 6.Department of CardiologySaiseikai Central HospitalTokyoJapan
  7. 7.Department of CardiologyNational Hospital Organization, Tokyo Medical CenterTokyoJapan
  8. 8.Center for Clinical ResearchKeio University School of MedicineTokyoJapan

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