Cardiovascular Intervention and Therapeutics

, Volume 26, Issue 3, pp 263–268

Very late stent thrombosis and neointimal plaque rupture after implantation of sirolimus-eluting stents: observations with angiography, IVUS and OCT

  • Nobuo Sakamoto
  • Kazuhiko Nakazato
  • Tomofumi Misaka
  • Hiroyuki Mizukami
  • Hiroyuki Kunii
  • Hitoshi Suzuki
  • Shu-ichi Saitoh
  • Yasuchika Takeishi
Case Report


Drug-eluting stent (DES) dramatically reduces the incidence of restenosis and rates of target lesion revascularization. Although several reports suggest that very late stent thrombosis could occur in patients after DES implantation, neointimal plaque rupture may be uncommon in the patients treated with DES compared with bare-metal stent. It is unclear that the reason why the patient in acute coronary syndrome (ACS) treated with DES has a high frequency of very late stent thrombosis and pathophysiological mechanisms of neointimal plaque rupture after DES implantation. We report a case of very late stent thrombosis with the findings of neontimal plaque rupture as well as incomplete stent apposition 4 years after sirolimus-eluting stent implantation in ACS.


Sirolimus-eluting stent (SES) Intravascular ultrasound (IVUS) Very late stent thrombosis Incomplete stent apposition (ISA) Neointimal plaque rupture 


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Copyright information

© Japanese Association of Cardiovascular Intervention and Therapeutics 2011

Authors and Affiliations

  • Nobuo Sakamoto
    • 1
  • Kazuhiko Nakazato
    • 1
  • Tomofumi Misaka
    • 1
  • Hiroyuki Mizukami
    • 1
  • Hiroyuki Kunii
    • 1
  • Hitoshi Suzuki
    • 1
  • Shu-ichi Saitoh
    • 1
  • Yasuchika Takeishi
    • 1
  1. 1.Department of Cardiology and HematologyFukushima Medical UniversityFukushimaJapan

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