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Journal of Community Genetics

, Volume 4, Issue 1, pp 1–7 | Cite as

The use of genealogy databases for risk assessment in genetic health service: a systematic review

  • Vigdis Stefansdottir
  • Oskar Th. Johannsson
  • Heather Skirton
  • Laufey Tryggvadottir
  • Hrafn Tulinius
  • Jon J. JonssonEmail author
Review

Abstract

The use of electronic genealogical databases facilitates the construction of accurate and extensive pedigrees for potential use in genetic services. Genealogy databases can be linked to specific disease databases, such as cancer registries, in order to increase the accuracy of pedigrees used, and inform the genetic risk assessment. To review the published literature on the use of genealogy databases to construct pedigrees for risk assessment in genetic health service, a systematic literature search was undertaken using 12 combined search terms to identify all relevant published articles. Data sources: EbscoHost, PubMed, Web of Science, Ovid and the “grey literature”, as well as the reference lists of identified studies. Of 1,035 titles identified, two papers described a study on the use of genealogy databases in cancer risk assessment and two were discussion papers. While authors of the four papers described the potential use of genealogy databases in clinical genetic services, such use has not been adequately investigated and further research is required.

Keywords

Genealogy databases Genetic service Cancer registry Risk assessment Systematic review Genealogy Databases Health services 

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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Vigdis Stefansdottir
    • 1
    • 7
  • Oskar Th. Johannsson
    • 2
  • Heather Skirton
    • 3
  • Laufey Tryggvadottir
    • 5
    • 7
  • Hrafn Tulinius
    • 6
  • Jon J. Jonsson
    • 1
    • 4
    • 6
    Email author
  1. 1.Department of Genetics and Molecular Medicine, LandspitaliThe National Univ. Hosp. of IcelandReykjavikIceland
  2. 2.Department of Medical Oncology, LandspitaliThe National Univ. Hosp. of IcelandReykjavikIceland
  3. 3.Faculty of Health, Education and SocietyPlymouth Univ.PlymouthUK
  4. 4.Department of Biochemistry and Molecular BiologyUniversity of IcelandReykjavikIceland
  5. 5.Icelandic Cancer RegistryReykjavikIceland
  6. 6.The Genetical Committee of the University of IcelandReykjavikIceland
  7. 7.Faculty of MedicineUniversity of IcelandReykjavikIceland

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