Hormones and Cancer

, Volume 9, Issue 1, pp 55–61 | Cite as

Statin Use and Breast Cancer Prognosis in Black and White Women

  • Amanda LeiterEmail author
  • Nina A. Bickell
  • Derek LeRoith
  • Anupma Nayak
  • Sheldon M. Feldman
  • Neil B. Friedman
  • Alison Estabrook
  • Tari A. King
  • Kezhen Fei
  • Rebeca Franco
  • Emily J. Gallagher
Original Paper


Studies show decreased risk of breast cancer recurrence and improved survival with statin use, but data on racial disparities regarding breast cancer prognosis and statin use are lacking. Our objective was to investigate if racial disparities in breast cancer prognosis can be partially explained by differences in pre-diagnosis statin use. Patients were identified from a prospective, multicenter study examining the effects of metabolic factors on breast cancer prognosis in Black and White women. Statin use, prognosis (as measured by Nottingham Prognostic Index), anthropometric, tumor, and socio-demographic characteristics were examined. Five hundred eighty-seven women (487 White, 100 Black) with newly diagnosed primary invasive breast cancer were recruited. Obesity was more prevalent in Black women than White women (47 vs 19%, p < 0.01); both groups had similar low-density lipoprotein (LDL) cholesterol levels (113 ± 41 vs 113 ± 36 mg/dl, p = 0.90). More Black women used statins than White women (18 vs 11%, p = 0.06). Black women had a worse prognosis in an adjusted model than White women (OR 2.13 95% CI 1.23–3.67). Statin use was not associated with prognosis in unadjusted (OR 1.03, 95% CI 0.53–2.0) and adjusted models (OR 1.14, 95% CI 0.56–2.31). In women with newly diagnosed breast cancer, Black women were more likely to be treated with statins than White women, contrary to previous studies. Black women had worse prognosis than White women, but this difference was not explained by differences in pre-diagnosis statin use. Our study suggests that differences in pre-diagnosis statin use do not contribute to racial disparities in breast cancer prognosis.


Author Contributions

Conception and design: A. Leiter, N.A. Bickell, D. Leroith, K. Fei, R. Franco, E.J. Gallagher

Development of methodology: A. Leiter, N.A. Bickell, D. Leroith, K. Fei, E.J. Gallagher

Acquisition of data: N.A. Bickell, A. Nayak, S. Feldman, N.B. Friedman, A. Estabrook, T.A. King

Analysis and interpretation of data: K. Fei, A. Leiter, N.A. Bickell, D. Leroith, E.J. Gallagher

Writing, review, and/or revision of the manuscript: A. Leiter, N.A. Bickell, D. Leroith, A. Nayak, S. Feldman, N.B. Friedman, T.A King, K. Fei, R. Franco, E.J. Gallagher

Administrative, technical, or material support: R. Franco

Funding Information

This work was supported by the National Cancer Institute (NCI) grant 1R01CA171558-01 (authors NAB and DL), NCI grant K08CA190779, and Tisch Cancer Institute Young Scientist Cancer Research Award, as funded by the JJR Foundation (author EJG).

Compliance with Ethical Standards

Conflict of Interest

The authors declare that there are no conflicts of interest.


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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Amanda Leiter
    • 1
    Email author
  • Nina A. Bickell
    • 1
    • 2
  • Derek LeRoith
    • 3
  • Anupma Nayak
    • 4
  • Sheldon M. Feldman
    • 5
  • Neil B. Friedman
    • 6
  • Alison Estabrook
    • 7
  • Tari A. King
    • 8
  • Kezhen Fei
    • 2
  • Rebeca Franco
    • 2
  • Emily J. Gallagher
    • 3
  1. 1.Department of MedicineIcahn School of Medicine at Mount SinaiNew YorkUSA
  2. 2.Department of Population Health Sciences and Policy, Center for Health Equity & Community Engaged ResearchIcahn School of Medicine at Mount SinaiNew YorkUSA
  3. 3.Division of Endocrinology, Diabetes and Bone Diseases, Department of MedicineIcahn School of Medicine at Mount SinaiNew YorkUSA
  4. 4.Department of PathologyIcahn School of Medicine at Mount SinaiNew YorkUSA
  5. 5.Department of SurgeryColumbia University Medical CenterNew YorkUSA
  6. 6.Department of SurgeryMercy Medical CenterBaltimoreUSA
  7. 7.Department of Surgery, Mount Sinai WestIcahn School of Medicine at Mount SinaiNew YorkUSA
  8. 8.Department of SurgeryMemorial Sloan Kettering Cancer CenterNew YorkUSA

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