Hormones and Cancer

, Volume 6, Issue 5–6, pp 237–246 | Cite as

Alcohol Consumption and Risk of Breast Cancer by Tumor Receptor Expression

  • Jun Wang
  • Xuehong Zhang
  • Andrew H. Beck
  • Laura C. Collins
  • Wendy Y. Chen
  • Rulla M. Tamimi
  • Aditi Hazra
  • Myles Brown
  • Bernard Rosner
  • Susan E. Hankinson
Original Paper

Abstract

In epidemiologic studies, alcohol consumption appears more strongly associated with risk of estrogen receptor (ER)-positive than ER-negative breast cancer. However, this association has not been assessed by other potentially relevant tumor markers, such as androgen receptor (AR) or insulin receptor (IR). In the prospective Nurses’ Health Study cohort, we evaluated alcohol consumption and breast cancer risk by individual tumor marker expression (i.e., ER, progesterone receptor [PR], AR, and IR) while controlling for other markers and also assessed the joint effect of these receptors. During 26 years follow-up of 106,037 women, 2552 invasive breast cancers contributed to the analysis. When all four markers were considered simultaneously, no significant heterogeneity of the alcohol and breast cancer association was observed by any of the markers. However, each increment in one drink per day was associated with 10 % (95 % confidence interval [CI] = 4 %, 15 %) and 9 % (95 % CI = 4 %, 15 %) increased risk of AR-positive and ER-positive breast cancer, respectively, while no increased risk was observed among AR-negative or ER-negative tumors. The association was independent of PR and IR expression. Assessment of the joint expression of hormone receptors revealed a significantly increased risk among AR+/ER+/PR+ (hazard ratio [HR] per drink/day = 1.11, 95 % CI = 1.06, 1.17) but not in other subgroups (e.g., AR−/ER−/PR−: HR = 0.99; 95 % CI = 0.88, 1.12). Our data suggest that the alcohol and breast cancer association may be more pronounced among ER-positive and/or AR-positive breast tumors. However, our data do not support an important role of IR in the association.

Keywords

Breast Cancer Estrogen Receptor Androgen Receptor Progesterone Receptor Breast Cancer Risk 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This study was supported by research grants CA166666, CA186107, and CA87969 from the National Institutes of Health and SAC 110014 from the Komen Foundation. We would like to thank the participants and staff of the Nurses’ Health Study for their valuable contributions as well as the following state cancer registries for their help: AL, AZ, AR, CA, CO, CT, DE, FL, GA, ID, IL, IN, IA, KY, LA, ME, MD, MA, MI, NE, NH, NJ, NY, NC, ND, OH, OK, OR, PA, RI, SC, TN, TX, VA, WA, and WY. The authors assume full responsibility for analyses and interpretation of these data.

Conflict of Interest

The authors declare that they have no conflict of interest.

Supplementary material

12672_2015_235_MOESM1_ESM.docx (14 kb)
Supplementary Table 1 (DOCX 13 kb)
12672_2015_235_MOESM2_ESM.docx (18 kb)
Supplementary Table 2 (DOCX 18 kb)

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Jun Wang
    • 1
  • Xuehong Zhang
    • 2
  • Andrew H. Beck
    • 3
  • Laura C. Collins
    • 3
  • Wendy Y. Chen
    • 2
    • 4
  • Rulla M. Tamimi
    • 2
    • 5
  • Aditi Hazra
    • 2
    • 5
  • Myles Brown
    • 4
  • Bernard Rosner
    • 2
    • 6
  • Susan E. Hankinson
    • 1
    • 2
    • 5
  1. 1.Department of Biostatistics and Epidemiology, School of Public Health and Health SciencesUniversity of Massachusetts AmherstAmherstUSA
  2. 2.Channing Division of Network Medicine, Department of MedicineBrigham and Women’s Hospital and Harvard Medical SchoolBostonUSA
  3. 3.Department of PathologyBeth Israel Deaconess Medical Center and Harvard Medical SchoolBostonUSA
  4. 4.Department of Medical OncologyDana Farber Cancer InstituteBostonUSA
  5. 5.Department of EpidemiologyHarvard T.H. Chan School of Public HealthBostonUSA
  6. 6.Department of BiostatisticsHarvard T.H. Chan School of Public HealthBostonUSA

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