Preparation of the Sm3+-Doped Magnetic Nanoparticles via Microwave-Assisted Polyol Synthesis
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Sm3+-doped magnetic nanoparticles (NPs) were prepared via microwave-assisted polyol synthesis in ethylene glycol, poly(ethylene glycol) and mixed ethylene glycol—poly(ethylene glycol) solutions. In present work, the effects of organic solvent composition on particle size, particle size distribution, extent of agglomeration, and samarium content in prepared NPs were studied. The synthesized NPs were characterized by several techniques as follows: X-ray diffraction (XRD), transmission electron microscopy (TEM), thermogravimetry (TGA) and X-Ray fluorescence (XRF) analysis. XRD and TEM results showed formation of ~6.0–17.9 nm NPs having different microstructure characteristics (average particle size, particle size distribution, and agglomeration). The TGA analysis indicated the presence of organic components on the surface of NPs. Cytotoxic activity of the prepared magnetic NPs towards HeLa cells was evaluated by using standard live/dead assay in comparison to a control solution. It was shown that prepared magnetic NPs are characterized by low toxicity that makes possible their use for biomedical applications.
KeywordsMagnetic nanoparticles HeLa cells Polyol synthesis Microwave-assisted synthesis Samarium-doped nanoparticles Iron oxide nanoparticles
This study was financially supported by grant of Russian Science Foundation (project no. 14-35-00051).
We thank Dr. Peter V. Zolotukhin and Anna A. Belanova (Evolution corporate group) for assistance with cytotoxicity test, and the Joint Research Center “Diagnostics of structure and properties of nanomaterials” of Belgorod National Research University for TGA and XRD measurements and to Dr. Andriy Budnyk (SFedU) for his contribution during preparation of the manuscript.
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