Pharmacological Correction of Hypoxic Conditions by Complexes of Zinc with N-Alkenylimidazoles
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Abstract
The discovery and development of effective antihypoxic drugs is an important issue in modern experimental and clinical pharmacology. Complexes of zinc containing imidazole cycles as ligands are promising candidates for the design of novel drugs, including pharmacotherapeutic tools for patient’s protection under conditions of oxygen deficiency. Herein, we report antihypoxic activity of zinc complexes with N-alkenylimidazoles, and, specifically, a novel drug Acyzol, which can be used as efficient antidote after poisoning by carbon monoxide and other combustion products.
Keywords
Zinc complexes N-alkenylimidazoles Acyzol Hypoxia Antihypoxic activityNotes
Acknowledgments
The work is performed according to the Russian Government Program of Competitive Growth of I.M. Sechenov First Moscow State University and Kazan Federal University.
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflicts of interest.
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