BioNanoScience

, Volume 6, Issue 3, pp 261–268 | Cite as

Calcium Carbonate-Based Mucoadhesive Microcontainers for Intranasal Delivery of Drugs Bypassing the Blood–Brain Barrier

  • T. N. Borodina
  • D. B. Trushina
  • I. V. Marchenko
  • T. V. Bukreeva
Article
First Online:

Abstract

There is an opinion in the medical associations that intranasal administration of medicine allows direct olfactory transfer of drugs into the central nervous system bypassing the blood–brain barrier. This approach could be a valuable solution to the problem of cerebral pathology treatment. We propose a new system of microcontainers for the delivery of an active component to the brain by intranasal administration. The microcontainers were fabricated on the base of porous calcium carbonate particles modified with mucoadhesive biocompatible polymer or polymer/surfactant coating. Loperamide was encapsulated in the proposed microcontainers as a model drug, which cannot pass the blood–brain barrier. The efficiency of microcontainers loaded with the anesthetic loperamide has been assessed by the formalin test in rats in vivo. The results of the in vivo experiments demonstrate decrease in the pain sensitivity after intranasal administration of proposed system, and benefit of mucoadhesive biocompatible coating aiming to improve the anesthetic effect.

Keywords

Calcium carbonate microparticles Microcontainers Drug delivery Intranasal administration Anesthetic Mucoadhesive polymer Avoidance of blood–brain barrier 
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Notes

Acknowledgments

We gratefully acknowledge the group of Prof. N.V. Gulyaeva (Functional Biochemistry of the nervous system Lab) for the performing of the in vivo experiments in the Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences. This study was performed using the equipment of the Shared Research Center of the Institute of Crystallography of the Russian Academy of Sciences and partially funded by the Russian Foundation for Basic Research and Moscow city Government according to the research project no. 15-33-70032 «mol_a_mos».

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • T. N. Borodina
    • 1
  • D. B. Trushina
    • 1
    • 2
    • 3
  • I. V. Marchenko
    • 1
    • 3
  • T. V. Bukreeva
    • 1
    • 3
  1. 1.Shubnikov Institute of Crystallography of Federal Scientific Research Centre “Crystallography and Photonics” of Russian Academy of SciencesMoscowRussia
  2. 2.Faculty of PhysicsLomonosov Moscow State UniversityMoscowRussia
  3. 3.National Research Centre “Kurchatov Institute”MoscowRussia

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