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BioNanoScience

, Volume 1, Issue 4, pp 123–127 | Cite as

Tropoelastin Switch and Modulated Endothelial Cell Binding to PTFE

  • Daniel V. Bax
  • Siyuan John Liu
  • David R. McKenzie
  • Marcela M. M. Bilek
  • Anthony S. WeissEmail author
Article

To the Editor:

Polytetrafluoroethylene (PTFE) is routinely modified and used for the fabrication of vascular conduits. In its untreated form, it displays low cell-binding activity which combined with persistent thrombogenicity limits its utility. Full endothelial cell coverage of the blood-contacting surface would present a more natural lumen interface and is likely reduce the thrombogenicity of vascular grafts. Thrombosis is the major cause of short-term failure of heart valves, coronary stents, and small-diameter synthetic grafts. The ECM protein tropoelastin, the precursor of elastin, has a role in signaling and regulating luminal endothelial cells in the arterial wall. Additionally, elastin possesses low thrombogenicity and is being assessed for its potential as a vascular conduit component [1]. Here, we explore the potential of coating polymers with tropoelastin to control endothelial cell interactions with the eventual goal of bestowing low thrombogenicity. There is a paucity of...

Keywords

PTFE Heparan Sulfate Vascular Graft Human Dermal Fibroblast Endothelial Cell Interaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

We gratefully acknowledge project funding from the Australian Research Council and the National Health & Medical Research Council. We thank Cochlear Ltd. and SpineCell Pty Ltd for financial and in-kind support. We thank Daniel Smyth for assistance and Yan Yee Poon, Rodrigo Vazquez-Lombardi, and Sarah Martinez for the technical assistance.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Daniel V. Bax
    • 1
    • 2
  • Siyuan John Liu
    • 3
  • David R. McKenzie
    • 1
  • Marcela M. M. Bilek
    • 1
  • Anthony S. Weiss
    • 2
    Email author
  1. 1.Applied and Plasma Physics, School of PhysicsUniversity of SydneySydneyAustralia
  2. 2.School of Molecular BioscienceUniversity of SydneySydneyAustralia
  3. 3.School of Medicine, University of California San FranciscoSan FranciscoUSA

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