Bridging the Scales to Explore Cellular Adaptation and Remodeling
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This short paper presents a multiscale framework to better understand the mechanisms of biological tissue evolution from molecular to tissue scale. For this, a bottom-up strategy is proposed in which mechano-sensitive molecular processes, the evolution of cell architecture and contraction as well as the interaction between cells and the extra-cellular matrix can be integrated in a single framework. Preliminary studies based on this approach suggest that mechano-sensitive feed-back mechanisms at several length-scales may be a key element to understand tissue adaptivity to tis mechanical environment.
KeywordsMultiscale modeling Biological tissue Evolution Cells
FJV gratefully acknowledges the University of Colorado CRCW Seed Grant in support of this research.
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