Health-related quality of life (HRQOL) is influenced by the disease state, associated complications and their management. In patients with liver cirrhosis co-morbidity, severity of liver disease and their complications are likely to affect the QOL. The aim of the study was to determine the factors that are likely to influence the domains of HRQOL using SF-36 in patients with liver cirrhosis. For the study, 149 patients with liver cirrhosis were compared with age-gender matched healthy controls for physical and mental components of SF-36 score and the effects of age, co-morbidity severity of liver disease and complications of liver cirrhosis on HRQOL were assessed using the same questionnaire. Results of the study showed that except for body pain, all the patients had a significantly low individual and composite domain score (p-value <0.0001) compared to age-gender matched controls. Patients below 45 years, Child-Turcotte-Pugh (CTP) C, a high model for end-stage liver disease (MELD) and higher rates of complication had low scores for body pain (KW p <0.005) and those above 55 years, for physical function (p <0.05). Both the physical components had a major impact on mental composite score (MCS) (KW p <0.05). Co-morbidity that included diabetes, hypertension and hypothyroid states in various combinations had no effect on SF-36 scores while co-morbid conditions like musculoskeletal pain, arthralgia etc. affected physical domains (physical function, body pain and role physical) and physical component score (PCS) (KW p <0.01 to <0.0001). By linear regression, MELD had a direct and significant association with overall PCS and mental component score (MCS).
Cirrhosis Liver Quality of life
This is a preview of subscription content, log in to check access.
Compliance with ethical standards
Conflict of interest
KJ, JV, MJ, KH, VS, TM, and VJ declare that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
Younossi ZM, Boparai N, McCormick M, Price LL, Guyatt G. Assessment of utilities and health-related quality of life in patients with chronic liver disease. Am J Gastroenterol. 2001;96:579–83.CrossRefPubMedGoogle Scholar
Marchesini G, Bianchi G, Amodio P, et al. Factors associated with poor health-related quality of life of patients with cirrhosis. Gastroenterology. 2001;120:170–8.CrossRefPubMedGoogle Scholar
Younossi ZM, Boparai N, Price LL, Kiwi ML, McCormick M, Guyatt G. Health-related quality of life of patients in chronic liver disease: the impact of type and severity of liver disease. Am J Gastroenterol. 2001;96:2199–205.CrossRefPubMedGoogle Scholar
Sobhonslidsuk A, Silpakit C, Kongsakon R, Satitporunkal P, Sripetch C. Chronic liver disease questionnaire translation and validation in Thais. World J Gastroenterol. 2004;10:1954–7.CrossRefPubMedPubMedCentralGoogle Scholar
Ray I, Dutta D, Basu P, De BK. Quality of life assessment of patients with chronic liver disease in eastern India using a Bengali transplantation chronic liver disease questionnaire. Indian J Gastroenterol. 2010;29:187–95.CrossRefPubMedGoogle Scholar
Ware JE Jr, Sherbourne CD. The MOS 36-item short-form health survey (SF-36): I. Conceptual framework and item selection, Med Care. 1992;30:473–83.Google Scholar
Rahimi RS, Rockey DC. Complications of cirrhosis. Current Opin Gastroenterol. 2012;28:223–9.CrossRefGoogle Scholar
Sobhonslidsuk A, Silpakit C, Kongsakon R, Satitporunkal P, Sripetch C, Khanthavit A. Factors influencing health-related quality of life in chronic liver disease. World J Gastroenterol. 2006;12:7786–91.CrossRefPubMedPubMedCentralGoogle Scholar
David K, Kowdley KV, Unalp A, Kanwal F, Brunt EM, Schwimmer JB. Quality of life in adults with nonalcoholic fatty liver disease: baseline data from the nonalcoholic steatohepatitis clinical research network. Hepatology. 2009;49:1904–12.CrossRefPubMedPubMedCentralGoogle Scholar
Hauser W, Holtman G, Grandi D. Determinants of health related quality of life in patients with chronic liver disease. Clin Gastroenterol Hepatol. 2004;2:157–63.CrossRefPubMedGoogle Scholar
Gutteling JJ, de Man RA, van der Plas SM, Schalm SW, Busschhbach JJ, Darlingtone AS. Determinants of quality of life in chronic liver patients. Aliment Pharmacol Ther. 2006;23:1629–35.CrossRefPubMedGoogle Scholar
Farivar SS, Cunningham WE, Hays RD. Correlated physical and mental health summary scores for the SF-36 and SF-12 health survey, V.1. Health Qual Life Outcomes. 2007;5:54.Google Scholar
Zuberi BF, Memom AR, Afsar S, Qadeer R, Kumar R. Correlation of quality of life in patients of cirrhosis of liver with etiology and disease severity using disease specific quality of life questionnaire. J Ayub Med Coll Abbottabad. 2007;19:7–11.PubMedGoogle Scholar
Arguedas MR, DeLawrence TG, McGuire BM. Influence of hepatic encephalopathy on health-related quality of life in patients with cirrhosis. Dig Dis Sci. 2003;48:1622–6.CrossRefPubMedGoogle Scholar