Indian Journal of Gastroenterology

, Volume 36, Issue 4, pp 313–317 | Cite as

HRQOL using SF36 (generic specific) in liver cirrhosis

  • K. Janani
  • Joy Varghese
  • Mayank Jain
  • Kavya Harika
  • Vijaya Srinivasan
  • Tom Michael
  • Venkataraman JayanthiEmail author
Short Report


Health-related quality of life (HRQOL) is influenced by the disease state, associated complications and their management. In patients with liver cirrhosis co-morbidity, severity of liver disease and their complications are likely to affect the QOL. The aim of the study was to determine the factors that are likely to influence the domains of HRQOL using SF-36 in patients with liver cirrhosis. For the study, 149 patients with liver cirrhosis were compared with age-gender matched healthy controls for physical and mental components of SF-36 score and the effects of age, co-morbidity severity of liver disease and complications of liver cirrhosis on HRQOL were assessed using the same questionnaire. Results of the study showed that except for body pain, all the patients had a significantly low individual and composite domain score (p-value <0.0001) compared to age-gender matched controls. Patients below 45 years, Child-Turcotte-Pugh (CTP) C, a high model for end-stage liver disease (MELD) and higher rates of complication had low scores for body pain (KW p <0.005) and those above 55 years, for physical function (p <0.05). Both the physical components had a major impact on mental composite score (MCS) (KW p <0.05). Co-morbidity that included diabetes, hypertension and hypothyroid states in various combinations had no effect on SF-36 scores while co-morbid conditions like musculoskeletal pain, arthralgia etc. affected physical domains (physical function, body pain and role physical) and physical component score (PCS) (KW p <0.01 to <0.0001). By linear regression, MELD had a direct and significant association with overall PCS and mental component score (MCS).


Cirrhosis Liver Quality of life 


Compliance with ethical standards

Conflict of interest

KJ, JV, MJ, KH, VS, TM, and VJ declare that they have no conflict of interest.

Ethical statement

All procedures performed in studies involving human participants were in accordance with the ethical standards of institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.


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Copyright information

© Indian Society of Gastroenterology 2017

Authors and Affiliations

  1. 1.Department of GastroenterologyGleneagles Global Health CityChennaiIndia
  2. 2.Institute of Liver Disease and TransplantationGleneagles Global Health CityChennaiIndia

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