Influence of probiotic administration on the fecal microbiota in diarrhea-predominant irritable bowel syndrome
There is a growing interest in the role of altered gastrointestinal (GI) microbiota in the pathogenesis of irritable bowel syndrome (IBS) [ 1]. Qualitative and quantitative changes in GI microbiota contributing to increased production of proinflammatory cytokines, organic acids, and gases (H 2, CH 4 and CO 2) have earlier been reported to alter water and electrolyte balance in the GI tract causing diarrhea-related symptoms in IBS [ 2, 3]. Recent reports on the beneficial effects of probiotic administration in IBS, by suppressing formation of proinflammatory cytokines and protecting the integrity of intestinal barrier functions, indicate that normalizing GI microbiota can be a useful strategy in the management of IBS [ 4]. In order to examine alterations in GI microbiota in diarrhea-predominant IBS (IBS-D) and to evaluate the beneficial effect of probiotic administration in such cases, we analyzed and compared fecal microbiota in Indian patients with IBS-D ( n = 10) and healthy controls ( n = 1...
KeywordsLactobacillus Irritable Bowel Syndrome Lactobacillus Acidophilus Fecal Microbiota Bifidobacterium Longum
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© Indian Society of Gastroenterology 2015