Indian Journal of Gastroenterology

, Volume 32, Issue 2, pp 103–107 | Cite as

Matrix metalloproteinase-9, transforming growth factor-β1, and tumor necrosis factor-α plasma levels in chronic pancreatitis

  • K. Sri Manjari
  • A. Jyothy
  • A. Vidyasagar
  • B. Prabhakar
  • Prathibha Nallari
  • A. Venkateshwari
Original Article

Abstract

Objective

The aim of the study was to investigate the plasma levels of matrix metalloproteinase-9 (MMP-9), transforming growth factor-β 1 (TGF-β1), and tumor necrosis factor-α (TNF-α) in chronic pancreatitis (CP).

Methods

Blood samples were obtained from 71 patients with CP and 100 control subjects, and plasma levels of MMP-9, TGF-β1, and TNF-α were determined by enzyme-linked immunosorbent assay.

Results

The plasma levels of MMP-9 (18.3 ± 3.0 ng/mL, p < 0.0001), TGF-β1 (215.4 ± 178.1 ng/mL, p = 0.0301), and TNF-α (111.2 ± 69.3 ng/mL, p < 0.001) were significantly elevated in CP compared to the control group.

Conclusion

The role of elevated plasma MMP-9, TGF-β1, and TNF-α in CP requires further evaluation.

Keywords

Extracellular matrix Pancreatic fibrosis Pancreatic stellate cells 

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Copyright information

© Indian Society of Gastroenterology 2013

Authors and Affiliations

  • K. Sri Manjari
    • 1
  • A. Jyothy
    • 1
  • A. Vidyasagar
    • 2
  • B. Prabhakar
    • 3
  • Prathibha Nallari
    • 4
  • A. Venkateshwari
    • 1
  1. 1.Institute of Genetics and Hospital for Genetic DiseasesOsmania UniversityHyderabadIndia
  2. 2.Department of GastroenterologyGandhi General HospitalHyderabadIndia
  3. 3.Department of GastroenterologyOsmania General HospitalHyderabadIndia
  4. 4.Department of GeneticsOsmania UniversityHyderabadIndia

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