Indian Journal of Gastroenterology

, Volume 31, Issue 2, pp 83–84 | Cite as

Non responsive celiac disease due to coexisting hereditary fructose intolerance

Case Report

Abstract

Celiac disease is associated with several genetic disorders, but its association with hereditary fructose intolerance is rare. Hereditary fructose intolerance is a rare autosomal recessive disease of fructose metabolism presenting as vomiting after intake of fructose. An association between these two distinct genetic gastrointestinal disorders is important as treatment failure of celiac disease calls for careful evaluation for hereditary fructose intolerance. We report a patient with an association of these two disorders.

Keywords

Failure to thrive Hepatomegaly 

Notes

Acknowledgement

The authors are grateful to Dr Madhavi Sharma, Pathologist, Fortis Escorts Hospital for laboratory support.

References

  1. 1.
    What is HFI? Available at: http://www.bu.edu/aldolase/HFI/ accessed Dec 10, 2009.
  2. 2.
    Ananth N, Praveenkumar GS, Aravind Rao K, Vasanthi, Srinivas K. Two cases of hereditary fructose intolerance. Indian J Clin Biochem. 2003;18:87–92.CrossRefGoogle Scholar
  3. 3.
    Sitadevi C, Ramaiah Y, Askari Z. Fructose intolerance associated with congenital cataract. Report of a case. Indian J Pediatr. 1968;35:496–8.PubMedCrossRefGoogle Scholar
  4. 4.
    Abdulkarim AS, Burgart LJ, See J, Murray JA. Etiology of non-responsive celiac disease: results of a systematic approach. Am J Gastroenterol. 2002;97:2016–21.PubMedCrossRefGoogle Scholar
  5. 5.
    Oberhuber G, Granditsch G, Vogelsang H. The histopathology of coeliac disease: time for a standardized report scheme for pathologists. Eur J Gastroenterol Hepatol. 1999;11:1185–94.Google Scholar
  6. 6.
    Krauss N, Schuppan D. Monitoring nonresponsive patients who have celiac disease. Gastrointest Endosc Clin N Am. 2006;16:317–27.PubMedCrossRefGoogle Scholar
  7. 7.
    Seliwanoff T. Berichte der deutschen chemischen Gesellschaft, 1887, 20:181–2. Available at http://en.wikipedia.org/wiki/Seliwanoff%27s_test accessed on 10th Dec 2009.
  8. 8.
    Yasawy MI, Folsch UR, Schmidt WE, Schwend M. Adult hereditary fructose intolerance. World J Gastroenterol. 2009;15:2412–3.PubMedCrossRefGoogle Scholar
  9. 9.
    Gitzelman R, Steinmann B, Van den Berghe G. Disorders of fructose metabolism. In: Scriver CR, Beaudet Al, Sly WS, Valle D, eds. The Metabolic and Molecular Bases of Inherited Disease. 7th ed. New York: McGraw-Hill Book Co; 1995. pp. 905–4.Google Scholar
  10. 10.
    Steinmann B, Gitzelmann R. The diagnosis of hereditary fructose intolerance. Helv Paediatr Acta. 1981;36:297–316.PubMedGoogle Scholar
  11. 11.
    Ciacci C, Gennarelli D, Esposito G, Tortora R, Salvatore F, Sacchetti L. Hereditary fructose intolerance and celiac disease: a novel genetic association. Clin Gastroenterol Hepatol. 2006;4:635–8.PubMedCrossRefGoogle Scholar
  12. 12.
    Black JA, Simpson K. Fructose intolerance. Brit Med J. 1967;4:138–41.PubMedCrossRefGoogle Scholar

Copyright information

© Indian Society of Gastroenterology 2012

Authors and Affiliations

  1. 1.Departments of Pediatrics and NeonatologyFortis Escorts HospitalJaipurIndia

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