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Pulmonary manifestations in inflammatory bowel disease: a prospective study

  • Devendra DesaiEmail author
  • Samir Patil
  • Zarir Udwadia
  • Shailendra Maheshwari
  • Philip Abraham
  • Anand Joshi
Original Article

Abstract

Background

Although pulmonary abnormalities have been recognized in patients with inflammatory bowel diseases (IBD), their prevalence and clinical significance are not known.

Aim

To study the prevalence and clinical significance of pulmonary abnormalities in patients with IBD.

Methods

Ninety-five non-consecutive patients with IBD (12 Crohn’s disease, 83 ulcerative colitis; mean age 41.9 [SD 13] years; 47 women) were prospectively studied from January 2007 to March 2010. Pulmonary function tests (PFT) and high-resolution CT (HRCT) chest were performed in them. PFT were compared to those in 270 healthy (control) subjects matched for age, sex and smoking status.

Results

Twenty-seven (28.5%) patients and 11 (4%) control subjects had abnormal PFT (p < 0.0001). Small airway obstruction was seen in 18 patients, restrictive defect in six and mixed defect in three. Twenty-one (22%) patients had abnormal HRCT findings – bronchiectasis and nodules (nine patients each, including one with nodules who later developed active tuberculosis after infliximab therapy), parenchymal bands (8), mediastinal lymphadenopathy (five, including two with tuberculosis on histology and culture), emphysema (5), brochiolitis (2), pleural effusion or thickening (2), pericardial effusion (2), patchy consolidation (1), ground-glass opacities (1) and lung metastasis (1). Three patients had symptoms (one asthma, two cough).

Conclusion

PFT and HRCT chest showed abnormality in about one-quarter of patients with IBD. A majority of patients with these abnormalities were asymptomatic.

Keywords

Diffusion abnormality Interstitial lung disease Lung function tests Pulmonary involvement 

Notes

Source of funding

This study was funded by the National Health and Education Society, Mumbai.

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Copyright information

© Indian Society of Gastroenterology 2011

Authors and Affiliations

  • Devendra Desai
    • 1
    Email author
  • Samir Patil
    • 1
  • Zarir Udwadia
    • 2
  • Shailendra Maheshwari
    • 3
  • Philip Abraham
    • 1
  • Anand Joshi
    • 1
  1. 1.Division of GastroenterologyP D Hinduja National HospitalMumbaiIndia
  2. 2.Chest Medicine, P D Hinduja National HospitalMumbaiIndia
  3. 3.Department of RadiologyP D Hinduja National HospitalMumbaiIndia

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