Role of Helicobacter pylori infection in the pathogenesis of minimal hepatic encephalopathy and effect of its eradication

  • Avinash Agrawal
  • Alok Gupta
  • Mam Chandra
  • Sciddhartha Koowar
Original Article


Background and Aim

Helicobacter pylori (H. pylori) bacteria convert urea to ammonia, which has been implicated in causation of hepatic encephalopathy in patients with liver cirrhosis. The role of H. pylori infection in causation of minimal hepatic encephalopathy (MHE) has not been well studied. We looked at the relationship of H. pylori infection with MHE and hyperammonemia in patients with liver cirrhosis and the effects of anti-H. pylori treatment in patients with MHE and H. pylori infection.


Patients with liver cirrhosis underwent psychometric tests for detection of MHE, rapid urease test to look for evidence of H. pylori infection and measurement of fasting blood ammonia levels. Patients with MHE were treated with triple-drug anti-H. pylori treatment for one week. Rapid urease test, blood ammonia levels, and psychometric tests were repeated four weeks after treatment.


H. pylori infection was found more often in patients with MHE (63%) than in those without MHE (37%). Blood ammonia levels were significantly higher in patients with MHE than those without. After H. pylori treatment in patients with MHE, blood ammonia levels showed a significant decline and psychometric test results returned towards normal.


In patients with liver cirrhosis, there is a significant association between H. pylori infection and MHE. Anti-H. pylori therapy results in reduction in blood ammonia levels and improvement in MHE.


Ammonia Liver cirrhosis Minimal hepatic encephalopathy 


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Copyright information

© Indian Society of Gastroenterology 2011

Authors and Affiliations

  • Avinash Agrawal
    • 1
  • Alok Gupta
    • 1
  • Mam Chandra
    • 1
  • Sciddhartha Koowar
    • 2
  1. 1.Department of MedicineChattarpati Shahuji Maharaj Medical UniversityLucknowIndia
  2. 2.Department of PediatricsChattarpati Shahuji Maharaj Medical UniversityLucknowIndia

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