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An Assessment of the Osteogenic Potential of Cissus quadrangularis in Mandibular Fractures: A Pilot Study

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Abstract

Background

A routine mandibular fracture matures in about 12 weeks and hence hinders normal function significantly. Alternatives are being researched to hasten the healing and allow early function. This prospective study aimed to assess the osteogenic potential of the drug Cissus quadrangularis (CQ) on the mandibular fracture healing.

Design

Prospective randomized study.

Results

The study between the groups revealed a statistically significant increase in the alkaline phosphatase levels in CQ group in comparison with control group. The radiographic findings (increment in density and rate of change of density), clinical findings (mobility, swelling, reduction in pain) and other biochemical findings (serum calcium, serum phosphorous) did not differ statistically between the CQ and control groups.

Conclusion

Based on the lack of a statistically significant improvement in almost all parameters except for the alkaline phosphatase levels, we believe that a larger sample size is required to ascertain the absolute value of CQ before adding it to the mandibular fracture regimen.

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Acknowledgements

We would like to thank Dr. Lalitha BR, Professor, Government Ayurveda College, Bangalore, who provided insight and expertise that greatly assisted in the current research.

Author information

Correspondence to Tulasi Nayak.

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Ethical Clearance

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Reference No. 02_D010_43915.

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Nayak, T., R, K. An Assessment of the Osteogenic Potential of Cissus quadrangularis in Mandibular Fractures: A Pilot Study. J. Maxillofac. Oral Surg. 19, 106–112 (2020). https://doi.org/10.1007/s12663-019-01230-z

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Keywords

  • Mandibular fracture
  • Fracture healing
  • Cissus quadrangularis
  • Ayurveda