Journal of Maxillofacial and Oral Surgery

, Volume 18, Issue 1, pp 73–79 | Cite as

Effect of Topical Application of Pure Honey in Chemo-radiation-Induced Mucositis and Its Clinical Benefits in Improving Quality of Life in Patients of Oral Squamous Cell Carcinoma

  • Debraj Howlader
  • Vibha SinghEmail author
  • Shadab Mohammad
  • Seema Gupta
  • U. S. Pal
  • Mahesh Pal
Comparative Study


Oral cancer is a major health problem in India, and in certain parts, it represents more than 50% of all cancers. Since almost all of these patients receive chemo-radiotherapy with or without surgery for treatment, a vast majority of them also develop oral mucositis, a debilitating adverse effect of chemo-radiation. There have been various reports in the literature regarding the beneficial role of honey in the management of oral mucositis. The objective of this study was to investigate whether the application of honey in mucositis confers any significant improvement in lesions of mucositis and more specifically whether application of honey brings about any improvement in the quality of life of patients suffering from chemo-radiation-induced oral mucositis. If found to be beneficial, honey could provide a simple, elegant and cost-effective solution to a troublesome health problem, thus benefiting a large number of patients.


Oral squamous cell carcinoma Radiotherapy Mucositis Honey Quality of life 


Author Contribution

D.H contributed to data collection and processing, V.S helped in conception of idea and study design, S.M. revised the intellectual content, S.G. involved in study design and study parameters, U.S.P. made critical review, and M.P. participated in logistic support.


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Copyright information

© The Association of Oral and Maxillofacial Surgeons of India 2018

Authors and Affiliations

  • Debraj Howlader
    • 1
  • Vibha Singh
    • 1
    Email author
  • Shadab Mohammad
    • 1
  • Seema Gupta
    • 2
  • U. S. Pal
    • 1
  • Mahesh Pal
    • 3
  1. 1.Department of Oral and Maxillofacial Surgery, Faculty of Dental SciencesKing George’s Medical UniversityLucknowIndia
  2. 2.Department of Radiation OncologyKing George’s Medical UniversityLucknowIndia
  3. 3.Department of PhytochemistryNational Botanical Research InstituteLucknowIndia

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