Journal of Maxillofacial and Oral Surgery

, Volume 14, Issue 2, pp 247–251 | Cite as

ANKH Polymorphisms and Clicking of the Temporomandibular Joint in Dental Residents

  • Boyen HuangEmail author
  • Katsu TakahashiEmail author
  • Tomoko Goto
  • Honoka Kiso
  • Manabu Sugai
  • Akira Shimizu
  • Shinji Kosugi
  • Kazuhisa Bessho
Research Paper



This study aimed to carry out a case-control research study to assess occurrence of clicking of the temporomandibular joint (TMJ) in order to establish the relationship between TMJ clicking and the genotype of “ANKH inorganic pyrophosphate transport regulator” (ANKH) polymorphisms.

Materials and Method

A sample of 41 first-year dental residents was selected. Each was examined using standard clinical procedures and genotyping techniques.


The participation rate was 91.8 %. The prevalence of TMJ clicking was 51.2 % (95 % CI: 35.7–66.7 %). Occurrence of TMJ clicking was not related to age, gender and genotypes of ANKH-OR as well as ANKH-TR polymorphisms (p ≥ 0.165).


A similar distribution of ANKH genotypes in TMJ clicking and asymptomatic individuals has been demonstrated by this study. A high percentage of TMJ clicking has been confirmed. Future investigations are indicated.


Temporomandibular disorders Clicking ANKH Polymorphism Oral surgeon 



This study was supported by a Grant-in-Aid for Scientific Research (B) from Japanese Society for the Promotion of Science. The authors would like to show appreciation to those staff and students who helped in this project.


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Copyright information

© Association of Oral and Maxillofacial Surgeons of India 2014

Authors and Affiliations

  • Boyen Huang
    • 1
    Email author
  • Katsu Takahashi
    • 2
    Email author
  • Tomoko Goto
    • 2
  • Honoka Kiso
    • 2
  • Manabu Sugai
    • 3
  • Akira Shimizu
    • 3
  • Shinji Kosugi
    • 4
  • Kazuhisa Bessho
    • 2
  1. 1.Department of Paediatric Dentistry, School of Medicine and DentistryJames Cook UniversityCairnsAustralia
  2. 2.Department of Oral and Maxillofacial Surgery, Graduate School of MedicineKyoto UniversitySakyo-kuJapan
  3. 3.Translational Research Center, Kyoto University HospitalKyoto UniversityKyotoJapan
  4. 4.Department of Biomedical Ethics, Graduate School of MedicineKyoto UniversityKyotoJapan

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