Randomized Double Blind Comparative Study on the Efficacy of Ibuprofen and Aceclofenac in Controlling Post-Operative Sequelae after Third Molar Surgery
- 98 Downloads
- 3 Citations
Abstract
Objective
To compare the efficacy of Ibuprofen and Aceclofenac in controlling pain, swelling and trismus following removal of impacted mandibular third molar teeth. To assess the patient’s acceptability of these drugs.
Methods
The present double blind study was conducted on 60 adult patients for the surgical removal of impacted mandibular third molars. Drugs administered were Ibuprofen and Aceclofenac. Both the drugs were packed separately and coded with equal in number. After removal of impacted mandibular third molars, following parameters were studied: (1) Analgesic activity, (2) Maximum mouth opening, (3) Swelling.
Results
The scores were recorded preoperatively and on 1st, 3rd, 5th and 7th postoperative day.
Conclusion
Ibuprofen has a marginal edge over Aceclofenac. Both the drugs were well accepted by the patients with no reported adverse effects.
Keywords
Ibuprofen Aceclofenac Third molarReferences
- 1.Bailey BMW, Zaki G, Rotman H et al (1993) A double blind comparative study of soluble aspirin and diclofenac dispersible in the control of postextraction pain after removal of impacted third molars. Int J Oral Maxillofac 22:238–241CrossRefGoogle Scholar
- 2.Jatin K, Lata J, Singh TPA (2007) Comparative study on the efficacy of rofecoxib and ibuprofen in controlling post-operative sequelae following third molar surgeries. J Maxillofac O Surg 6(1):17–21Google Scholar
- 3.Seymour RA, Frame J, Negus TW, Hawkesford JE (1998) The comparative efficacy of aceclofenac and ibuprofen in postoperative pain after third molar surgery. Br J Oral Maxilofac Surg 36:375–379CrossRefGoogle Scholar
- 4.Goodman, Gilman (1996) The pharmacological basis of therapeutics, 9th edn. The McGraw Hill Companies Inc, New YorkGoogle Scholar
- 5.Tripathi KD (1999) Essentials of medical pharmacology fourth edition. Jaypee Brothers Publishers (P) Ltd, New DelhiGoogle Scholar
- 6.Mohamed AM, Daniel LM (1983) Prophylactic use of indomethacin for prevention of postsurgical complications after removal of impacted third molars. J Oral Surg 55:448–451CrossRefGoogle Scholar
- 7.Garcia GA, Sampedro GF, Rey GJ, Torreira GM (1997) Trismus and pain after removal of impacted lower third molars. J Oral Maxillofac Surg 55:1223–1226CrossRefGoogle Scholar
- 8.Habib S, Mathews RW, Scully S (1990) MRCPath. A study of the comparative efficacy of four common analgesics in the control of postsurgical pain. Oral Surg Oral Med Oral Path 70:559–563PubMedCrossRefGoogle Scholar
- 9.Vogel IR, Desjardins JP, Major VK (1992) Comparison of presurgical and immediate postsurgical ibuprofen on postoperative periodontal pain. J Periodontol 63:914–918PubMedGoogle Scholar
- 10.McQuay CD, Guest PG, Robson S (1993) A multiple dose comparison of ibuprofen and dihydrocodeine after third molar surgery. Br J Oral Maxillofac Surg 31:95–100PubMedCrossRefGoogle Scholar
- 11.Van GAV, Ten BJJ, Boering G (1975) A photographic method of assessing swelling following third molar removal. Int J Oral Surg 4:121–129CrossRefGoogle Scholar
- 12.Holland CS (1979) The development of a method of assessing swelling following third molar surgery. Br J Oral Maxillofac Surg 17:104–114Google Scholar
- 13.Ucok C (1997) Stereophotogrammetric assessment of the effect of tenoxicam on facial swelling subsequent to third molar surgery. Int J Oral Maxillofac Surg 26:380–382PubMedCrossRefGoogle Scholar
- 14.Forsgren H, Heimdahl A, Johansson B, Leonard K (1985) Effect of application of cold dressings on the postoperative course in oral surgery. Int J Oral Surg 14:223–228PubMedCrossRefGoogle Scholar
- 15.Schultze MS, Schmelzeisen R, Frolich JC, Schmele H (1995) Use of ibuprofen and methylprednisolone for the prevention of pain and swelling after removal of impacted third molars. J Oral Maxillofac Surg 53:2–7CrossRefGoogle Scholar
- 16.Bridgman JB, Gillgrass TG, Zacharias M (1996) The absence of any pre-emptive analgesic effect for non-steroidal anti-inflammatory drugs. Br J Oral Maxillofac Surg 34:428–431PubMedCrossRefGoogle Scholar
- 17.Ustin Y, Erdogan O, Esen E, Karsli DE (2003) Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 96:535–539CrossRefGoogle Scholar
- 18.van der Westhuijzen AJ, Becker PJ, Morkel J, Roelse JA (2005) A randomized observer blind comparison of bilateral facial ice pack therapy with no ice therapy following third molar surgery. Int J Oral Maxillofac Surg 34:281–286PubMedCrossRefGoogle Scholar
- 19.Buyukkurt MC, Gungormus M, Kaya O (2006) The effect of a single dose prednisolone with and without diclofenac on pain, trismus, and swelling after removal of mandibular third molars. J Oral Maxillofac Surg 64:1761–1766PubMedCrossRefGoogle Scholar
- 20.Calvo AM, Sakai VT, Giglio FPM, Modena KCS (2007) Analgesic and anti-inflammatory dose-response relationship of 7.5 and 15 mg meloxicam after lower third molar removal: a double-blind, randomized, crossover study. Int J Oral Maxillofac Surg 36:26–31PubMedCrossRefGoogle Scholar