The objective of this research is to increase the diagnostics and the radiotherapy efficiency enhancing the effective atomic number of cancer tissues using the injection of gold nanoparticles. The proposed method employs spheroidal gold nanoparticles, with an average diameter of about 10 nm, prepared using Nd:YAG laser ablation in water. Their distribution in tumor tissues can be obtained by local injection, by transport through the blood flux or by using functionalized nanoparticles transported in specific organs. The characterization of the nanoparticles was made by electron microscopy, characteristic X-ray fluorescence and optical absorbance investigation in the UV–visible region. The calculations demonstrate that the mass attenuation coefficients for X-rays and the proton stopping power in the tissue with nanoparticles increase significantly using a 0.1% concentration in weight. In conclusion, the presence of gold nanoparticles in the cancer tissues enhances significantly the cross section of the photoelectric effect for X-ray absorption and the stopping power of incident energetic protons, allowing the higher dose release. The releasing of nanoparticles only in the tumor site and not in the healthy tissues remains the most important problem to be resolved. The advances of this research concern, mostly, on acquisition of knowledge about the employment of nanoparticles locally injected in tumor site, to significantly enhance the contrast image and the dose released during radiotherapy with X-rays and proton beams.
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H Matsudaira, A M Ueno and I Furuno Radiat. Res.84 144 (1980)
R Santos Mello, H Callisen, J Winter, A R Kagan and A Norman Med. Phys.10 75 (1983)
L Torrisi, N Restuccia, S Cuzzocrea, I Paterniti, I Ielo, S Pergolizzi, et al. Gold Bull.50 51 (2017)
P M Tiwari, K Vig, V A Dennis and S R Singh Nanomaterials1 31 (2011)
A M Garcia J. Appl. Phys. 44 283001 (2011)
G Hegyi, G P Szigeti and A Szász Evid. Based Complement Altern. Med. 2013 672873 (2013)
A Juarranz, P Jaén, F Sanz-Rodríguez, J Cuevas and S González Clin. Transl. Oncol.10 148 (2008)
L C Feldman and J W Mayer Fundamentals of Surface and Thin Film Analysis (North-Holland, New York) (1986)
P Podsiadlo, V A Sinani, J H Bahng, N W S Kam, J Lee and N A Kotov Langmuir24 568 (2008)
X Huang, P K Jain, I H El-Sayed and M A El-Sayed Lasers Med. Sci.23 217 (2008)
L Torrisi Recent Patents Nanotechnol.9 51 (2015)
L Torrisi, N Restuccia and I Paterniti Recent Patents Nanotechnol.12 59 (2018)
J H Hubbell and S M Seltzer NIST, X-Ray Mass Attenuation Coefficients, Actual website 2019: https://www.nist.gov/pml/x-ray-mass-attenuation-coefficients
M J Berger, J S Coursey, M A Zucker and J Chang Stopping-Power and Range Tables for Electrons, Protons, and Helium Ions, Actual website 2019: https://www.nist.gov/pml/stopping-power-range-tables-electrons-protons-and-helium-ions
J Ziegler SRIM, The Stopping and Range of Ions in Matter, Actual website 2019: http://www.srim.org/
L Torrisi and A Torrisi Radiat. Eff. Def. Solids173 729 (2018)
T I Marshall, P Chaudhary, A Michaelidesová, J Vachelová, M Davídková, V Vondráček, G Schettino and K M Prise Int. J. Radiat. Oncol. Biol. Phys.95 70 (2016)
W N Rahman, N Bishara, T Ackerly, C F He, P Jackson, C Wong, R Davidson and M Geso Nanomed. Nanotechnol. Biol. Med.5 136 (2009)
D Sardari, A Abbaspour, S Baradaran and F Babapour Appl. Radiat. Isot.67 1438 (2009)
H Paganetti (ed.) Proton Therapy Physics (CRC Press, T&F Group, Boca Raton) (2012)
R C Murty Nature207 398 (1965)
L Torris and N Restuccia IRBM39 307 (2018)
G A P Cirrone, G Cuttone, P A Lojacono, S L Nigro, V Mongelli, I V Patti, et al. IEEE Trans. Nucl. Sci.51 860 (2004)
L Shang, K Nienhaus and GU Nienhaus J. Nanobiotechnol.12 5 (2014)
L Torrisi, N Restuccia and I Paterniti Recent Patents Nanotechnol.12 59 (2017)
This research was supported by University of Messina Research & Mobility 2016 Project (project code RES_AND_MOB_2016_TORRISI), Project No. 74893496. Many thanks to the CATANA Research group of INFN-LNS of Catania.
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Torrisi, L. Physical aspects of gold nanoparticles as cancer killer therapy. Indian J Phys (2020) doi:10.1007/s12648-019-01679-1
- Gold nanoparticles
- Laser ablation
- Ion energy loss