Elevated Hs-CRP Levels Are Associated with Higher Risk of Intracranial Arterial Stenosis

  • Bing-Jie Su
  • Yi Dong
  • Chen-Chen Tan
  • Xiao-He Hou
  • Wei Xu
  • Fu-Rong Sun
  • Mei Cui
  • Qiang DongEmail author
  • Lan TanEmail author
  • Jin-Tai YuEmail author
Original Article


Correlation between the level of high-sensitivity C-reactive protein (hs-CRP) and the incidence of intracranial arterial stenosis (ICAS) is unclear. We aim to investigate the relationship between hs-CRP levels and ICAS. A total of 1458 patients aged ≥ 40 years were enrolled in this study. All the participants had a magnetic resonance angiography (MRA) examination for the evaluation of ICAS. Participants were classified into four groups according to stroke and ICAS. Multivariable logistic regression models were used to assess the relationship of hs-CRP levels and ICAS status. A total of 432 (29.63%) subjects had ICAS. The levels of hs-CRP in stroke group were significantly higher than those in non-stroke group (p < 0.001). Patients with ICAS tend to have higher hs-CRP levels (p < 0.001). In multivariate analysis, the fourth hs-CRP quartile had the strongest association with ICAS in both stroke group and non-stroke group (OR 2.512, 95% CI 1.651–3.853, p < 0.001 for stroke group, and OR 2.534, 95% CI 1.435–4.595, p = 0.002 for non-stroke group) among the four quartiles of hs-CRP levels. Our study suggests that elevated serum hs-CRP levels are associated with higher risk of ICAS, in both stroke patients and non-stroke participants.


High-sensitivity C-reactive protein Intracranial arterial stenosis Stroke Atherosclerosis Inflammation 



anterior cerebral artery


acute ischemic stroke


basilar artery


high-density lipoprotein


high-sensitivity C-reactive protein


internal carotid artery


intracranial arterial stenosis




low-density lipoprotein


middle cerebral artery


magnetic resonance angiography


non-acute ischemic stroke


posterior cerebral artery


total cholesterol




vertebral artery



We thank all the study participants for their assistants and supports.

Author Contributions

JTY, LT, and QD conceptualized the study, analyzed and interpreted the data, and drafted and revised the manuscript. BJS, YD, and CCT analyzed and interpreted the data, drafted and revised the manuscript, did the statistical analysis, and prepared all the figures. XHH, WX, MC, and FRS did the interpretation of the data and revision of the manuscript. All authors contributed to the writing and revisions of the paper and approved the final version.

Funding Information

This study was supported by grants from the Taishan Scholars Program of Shandong Province (ts201511109 and tsqn20161079) and Qingdao Key Health Discipline Development Fund; Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX01) and ZHANGJIANG LAB; Tianqiao and Chrissy Chen Institute; and the State Key Laboratory of Neurobiology and Frontiers Center for Brain Science of Ministry of Education, Fudan University.

Compliance with Ethical Standards

Written informed consent form was obtained from all participants or their legal representatives. This study was approved by the Institutional Ethics Committees of Qingdao Municipal Hospital

Conflict of Interest

The authors declare that they have no conflicts of interest.


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Authors and Affiliations

  1. 1.Department of Neurology, Qingdao Municipal HospitalQingdao UniversityQingdaoChina
  2. 2.Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical CollegeFudan UniversityShanghaiChina

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