Retinol-Binding Protein 4 Predicts Lesion Volume (Determined by MRI) and Severity of Acute Ischemic Stroke
- 46 Downloads
Retinol-binding protein 4 (RBP4) is an adipocyte-secreted molecule and is associated with cardiovascular risk factors. The aim of this study was to assess the clinical significance of serum levels of RBP4 in Chinese patients with acute ischemic stroke (AIS). We sequentially screened patients with first-ever AIS who were admitted to our Hospital between September 2016 and October 2017. Serum levels of RBP4 were assayed with solid-phase sandwich ELISA, and severity of stroke was evaluated with the National Institutes of Health Stroke Scale (NIHSS) score on admission. We used logistic regression models to assess the relationship between RBP4 levels and stroke risk and severity. During the inclusion period, 323 patients completed the study. Our results indicated that the median serum RBP4 levels were significantly (P < 0.001) higher in patients with AIS than in those normal cases [28.9 (IQR, 17.3–39.6) μg/ml vs. 23.7 (14.6–32.3) μg/ml]. In logistic regression analysis, for each 1 unit increase of serum level of RBP4, the unadjusted and adjusted risks of AIS increased by 4% (OR 1.04 [95% CI 1.02–1.05], P < 0.001) and 3% (1.03 [1.01–1.04], P < 0.001), respectively. At admission, 116 patients (35.9%) had a minor stroke (NIHSS < 6). In logistic regression analysis, for each 1 unit increase of serum level of RBP4, the unadjusted and adjusted risks of moderate-to-high stroke increased by 7% (OR 1.07 [95% CI 1.05–1.09], P < 0.001) and 5% (1.05 [1.02–1.07], P < 0.001), respectively. Elevated levels of RBP4 could be considered an independent diagnosis marker of AIS. Elevated levels of RBP4 were significantly associated with higher stroke severity in Chinese sample.
KeywordsAcute ischemic stroke Retinol-binding protein 4 Oxidative stress Risk Chinese
We express our gratitude to all the patients who participated in this study, and thereby made this work possible.
All authors have contributed significantly, and that all authors are in agreement with the content of the manuscript.
Compliance with Ethical Standards
The content has not been published or submitted for publication elsewhere.
Conflict of Interest Statement
The authors declare that they have no conflicts of interest.
Ethics, Consent and Permissions
The present study has been approved by the ethics committee of the Cangzhou Central Hospital. All participants or their relatives were informed of the study protocol and their written informed consents were obtained.
- Agasthi P, Aloor S, Chenna A, Harris R (2015) Association between serum retinol binding protein-4 level and coronary artery disease: a meta-analysis. Arterioscler Thromb Vasc Biol 35:A344Google Scholar
- Lee SA, Kallianpur A, Xiang YB, Wen W, Cai Q, Liu D, Fazio S, Linton MF, Zheng W, Shu XO (2007) Intra-individual variation of plasma adipokine levels and utility of single measurement of these biomarkers in population-based studies. Cancer Epidemiol Prev Biomark 16(11):2464–2470CrossRefGoogle Scholar
- Liu G, Ding M, Chiuve SE, Rimm EB, Franks PW, Meigs JB, ... & Sun Q (2016) Plasma levels of fatty acid–binding protein 4, retinol-binding protein 4, high-molecular-weight adiponectin, and cardiovascular mortality among men with type 2 diabetes: a 22-year prospective study. Arteriosclerosis, thrombosis, and vascular biology 36:2259–2267Google Scholar
- Tu WJ, Zeng XW, Deng A, Zhao SJ, Luo DZ, Ma GZ., ... & Liu Q (2017b) Circulating FABP4 (fatty acid–binding protein 4) is a novel prognostic biomarker in patients with acute ischemic stroke. Stroke; 48(6): 1531–1538Google Scholar