Efficacy of closantel, fenbendazole and ivermectin against GI helminths of cattle in central Kashmir
- 37 Downloads
Three trials were conducted to evaluate the therapeutic efficacy of closantel (@ 7.5 mg/kg body weight, orally), fenbendazole (@ 7.5 mg/kg body weight, orally) and ivermectin bolus (@ 0.2 mg/kg body weight, orally) against gastrointestinal (GI) helminth parasites of cattle in central zone of Kashmir valley. Twenty cattle suffering from GI helminth infection were randomly selected and divided into two groups in each trial. In each trial, one group comprising of fifteen animals were treated with anthelmintic and second group comprising of five animals were kept as infected untreated control. To determine the therapeutic efficacy of different anthelmintic drugs against GI helminths, faecal samples were directly collected from rectum before treatment and on 7th, 14th and 28th day post treatment and eggs per gram of faeces was determined by using Stoll’s method. Then the efficacy of different anthelmintics was calculated by employing Faecal Egg Count Reduction Test. On 14th day post treatment closantel was found to be 100 and 94.44% effective against Fasciola spp. and strongyle worms, respectively, however, it was not found effective against Trichuris spp. The efficacy of fenbendazole was 100% against Fasciola spp., paramphistomes, Moniezia spp., Trichuris spp. and strongyle worms on 14th day post treatment. Ivermectin was found to be 100% effective against Trichuris spp. and strongyle worms on 14th day post treatment, however, it was not effective against Fasciola spp. and paramphistomes.
KeywordsClosantel Efficacy Fenbendazole Ivermectin Gastrointestinal helminths Cattle
The authors are thankful to staff members especially Mr. Mohd. Amin Wani, Division of Veterinary Parasitology, FVSc and AH SKUAST-K, Shuhama, Alusteng for providing all the necessary and timely help in carrying out the work. The funds for this research were met from Divisional ROC provided by SKUAST-K.
BM executed the research work in the field; RAS designed the technical programme of the research work; IMA assisted in data analysis and writing of the manuscript; ZAW assisted at field level during execution of the research work.
Compliance with ethical standard
Conflict of interest
The authors declare that there is no conflicts of interest.
Human and animal rights
The authors declare that the study was conducted on naturally infected animals in the field. As no experimental infection was established during this research work, so there was no need to take the approval for execution of the work from animal ethics committee. The animals belonged to the local farmers of the central Kashmir and they had given full consent for this research work.
- Aiman (2014) Prevalence and therapeutic studies on gastrointestinal helminth parasites of cattle in North zone of Kashmir valley. M. V. Sc thesis submitted to Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, ShalimarGoogle Scholar
- Bagherwal RK (1992) Efficacy of fenbendazole against helminth of dairy buffaloes and calves. Livestock Adviser 17:18–20Google Scholar
- Ibarra-Velarde F, Cristino NM, Vera-Montenegro Y, Bocanegra RC, Campos AH, Galvan PO (2002) Comparative efficacy of experimental fasciolicide, triclabendazole and closantel in cattle naturally infected with Fasciola hepatica. Vet Mexico 33:237–245Google Scholar
- Irshad (2015) Prevalence and therapeutic studies on gastrointestinal helminth parasites of cattle in South zone of Kashmir valley. M. V. Sc thesis submitted to Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, ShalimarGoogle Scholar
- Jaiswal AK, Sudan V, Shanker D, Kumar P (2013) Emergence of Ivermectin resistance in gastrointestinal nematodes of goats in a semi-organised farm of Mathura district-India. Vet Archive 83:275–280Google Scholar
- Kumar A, Prasad KD, Kumar RR (2004) Efficacy of ivermectin and tetramisole control packages against gastrointestinal nematodosis in cattle and buffaloes. J Vet Parasitol 18:31–33Google Scholar
- Manfredi MT, Rocco M, Rosa M, Bossi P, Traldi G, Genchi C (1988) Efficacy of ivermectin as atopical formulation in the treatment of endoparasites and ectoparasites of feedlot cattle. Obiettivi e Documenti Veterinari 9:53–55Google Scholar
- Mendoza-de-Gives P, Lopez Arellano ME, Ramblas Angeles JA, Najera Fuentes RA, Herrera Rodriguez D, Mejia Garcia RA (1986) Anthelmintic efficacy of ivermectin against gastrointestinal nematodes in cattle. Tecnica Pecuaria en Mexico 51:28–36Google Scholar
- Rajkhowa S, Bujarbaruah KM, Thong K, Rajkhowa C (2003) Comparative efficacy of ivermectin, levamisole and albendazole against naturally acquired nematodiasis of mithun. Ind Vet J 80:854–856Google Scholar
- Sahoo N, Mohanty TN, Sambal S (2002) Prevalence of gastrointestinal helminthic infection among grazing and stall-fed cattle in rainfed district of Orissa. J Vet Parasitol 16:61–62Google Scholar
- Sahoo N, Mohanty TN, Ray TK, Rao SV, Mallick B (2003) Effect of fenbendazole on milk production in gastro-intestinal nematode infected indigenous cows. Ind Vet J 80:570–571Google Scholar
- Sarkar AK, Ali M, Rahman A (2005) Efficacy of ivermectin against gastrointestinal nematodes in calves. J Anim Vet Adv 4:329–331Google Scholar
- Shin-Sung S, Lee-Chung G, Cho-Shinn H, Kim-Jong T, Wee-Sung H, Shin S (1995) Efficacy of closantel for the treatment of naturally acquired and experimentally induced Fasciola hepatica infections in cattle. K J Vet Res 35:347–352Google Scholar
- Soulsby EJL (1982) Helminths, arthopods and protozoa of domesticated animals, 7th edn. ELBS and Baillere Tindal, London, p 809Google Scholar