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Reduced fasting blood glucose levels following relapse in diminazene aceturate (Dinazene®) treated Trypanosoma brucei infected albino rats

  • Ikenna O. Ezeh
  • Nnenna E. Ugwu
  • Chukwunonso F. ObiEmail author
  • Vivian O. Enemuo
  • Micheal I. Okpala
  • Romanus Ezeokonkwo
Short Communication

Abstract

The blood glucose levels of rats were assessed following experimental Trypanosoma brucei infection and diminazene aceturate treatment. Ten adult female albino rats were randomly assigned into two groups of five rats each. Group A were infected with 106 trypanosomes while group B served as the uninfected control group. Group A rats were treated with 7 mg/kg Dinazene® (diminazene aceturate) at the peak of parasitaemia. Blood glucose level was assayed weekly while parasitaemia level was assessed daily. The blood glucose levels of the infected rats did not vary significantly (P > 0.05) from that of control group except following relapse when the values became significantly (P < 0.05) low. The implications of blood glucose reduction following relapse infection in rats is therefore highlighted and discussed.

Keywords

Fasting blood glucose levels Relapse infection Diminazene aceturate Trypanosoma brucei Rats 

Notes

Authors’ contributions

IOE and RE designed the study. NEU, VOE, CFO, MIO and IOE carried out the laboratory experiment. IOE performed the statistical analysis while NEU, CFO and IOE drafted the manuscript. The final version of the manuscript was read, revised critically and approved by all the authors.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Indian Society for Parasitology 2019

Authors and Affiliations

  • Ikenna O. Ezeh
    • 1
  • Nnenna E. Ugwu
    • 2
  • Chukwunonso F. Obi
    • 1
    Email author
  • Vivian O. Enemuo
    • 1
  • Micheal I. Okpala
    • 1
  • Romanus Ezeokonkwo
    • 1
  1. 1.Department of Veterinary Parasitology and EntomologyUniversity of NigeriaNsukkaNigeria
  2. 2.Department of Veterinary SurgeryUniversity of NigeriaNsukkaNigeria

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