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Journal of Parasitic Diseases

, Volume 40, Issue 4, pp 1586–1589 | Cite as

Seroprevalence of toxoplasmosis in diabetic pregnant women in southwestern of Iran

  • Jasem SakiEmail author
  • Shahla Shafieenia
  • Masoud Foroutan-Rad
Original Article

Abstract

To investigate anti-Toxoplasma gondii IgG and IgM antibodies in diabetic pregnant women in Ahvaz, southwest of Iran this experiment was performed. In current study the sera of 110 diabetic pregnant women as well as 110 non diabetic pregnant women referred to the hospitals affiliated with the Ahvaz Jundishapur University of Medical Sciences were assessed for anti-T. gondii IgG and IgM antibodies by ELISA and IFA methods. The ELISA assessments showed that 47 (42.7 %) and 3 (2.7 %) of diabetic women were positive for IgG and IgM antibodies, respectively. However, in the control group, 24 individuals (21.81 %) were positive for IgG antibody but no detection for IgM antibody. According to IFA method, 46 (41.8 %) and 3 (2.7 %) of diabetic women were positive for IgG and IgM antibodies, respectively, while in control group, 21 individuals (19.09 %) were positive for IgG antibody. In this method, IgM antibody was negative for all samples of control group (0 %). In both methods, the values obtained in the case group were significantly higher than those in the control group (p < 0.05). Prevalence of anti-Toxoplasma IgG and IgM antibodies in diabetic pregnant women was higher than that in non-diabetic pregnant women. It seems that screening tests for seeking patients and teaching the transmission routes should be considered as prenatal cares for diabetic women.

Keywords

Seroprevalence Toxoplasma gondii Diabetes Pregnancy 

Notes

Acknowledgments

We thank honorable colleagues and staff of laboratory, internal and gynecology departments, diabetes clinics, Golestan, Imam Khomeini, Razi, Aria hospitals and Matorian private Medical Diagnostic Laboratory for their cooperation in selecting study subjects and providing samples. This research was financially supported by the Research Department of Ahvaz Jundishapur University of Medical Sciences (No. D89015).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical Statement

Before collecting blood samples a written informed consent was obtained from all individual participants included in the study. It is worth mentioning that present study was approved by the ethic committee of Ahvaz Jundishapur University of Medical Sciences (No. ETH-1392.121).

References

  1. Akhlaghi L, Gharavi M, Faghihi A, Jabbari M (2005) Survey on the prevalence rates of intestinal parasites in diabetic patients in Karaj and Savodjbolagh Cities. Razi J Med Sci 12(45):23–29Google Scholar
  2. Daryani A et al (2014) Seroprevalence of Toxoplasma gondii in the Iranian general population: a systematic review and meta-analysis. Acta Trop 137:185–194. doi: 10.1016/j.actatropica.2014.05.015 CrossRefPubMedGoogle Scholar
  3. Gharavi MJ, Oormazdi H, Roointan ES (2008) A comparative study on sensitivity and specificity of conventional and unconventional IgG and IgM assays for diagnosis of toxoplasmosis. Iran J Public Health 37(4):42–45Google Scholar
  4. Ghasemian M, Maraghi S, Saki J, Pedram M (2007) Determination of antibodies (IgG, IgM) against Toxoplasma gondii in patients with cancer. Iran J Parasitol 2(4):1–6Google Scholar
  5. Gokce C, Yazar S, Bayram F, Gundogan K, Yaman O, Sahin I (2008) Anti-Toxoplasma gondii antibodies in type 2 diabetes. Natl Med J India 21(1):51PubMedGoogle Scholar
  6. Khademvatan S, Khajeddin N, Saki J, Izadi-Mazidi S (2013) Effect of toxoplasmosis on personality profiles of Iranian men and women. S Afr J Sci 109(1–2):92–95. doi: 10.1590/sajs.2013/0017 Google Scholar
  7. Khademvatan S, Abdizadeh R, Rahim F, Hashemitabar M, Ghasemi M, Tavalla M (2014) Stray cats gastrointestinal parasites and its association with public health in ahvaz city, South Western of iran. Jundishapur J Microbiol 7(8):e11079. doi: 10.5812/jjm.11079 PubMedPubMedCentralGoogle Scholar
  8. Lindberg RE, Frenkel JK (1977) Cellular immunity to toxoplasma and besnoitia in hamsters: specificity and the effects of cortisol. Infect Immun 15(3):855–862PubMedPubMedCentralGoogle Scholar
  9. Neva FA, Brown HW (1994) Basic clinical parasitology. Appleton & Lange, E. Norwalk, CTGoogle Scholar
  10. Ocak S, Zeteroglu S, Ozer C, Dolapcioglu K, Gungoren A (2007) Seroprevalence of Toxoplasma gondii, rubella and cytomegalovirus among pregnant women in southern Turkey. Scand J Infect Dis 39(3):231–234. doi: 10.1080/00365540600978880 CrossRefPubMedGoogle Scholar
  11. Rayfield EJ, Ault MJ, Keusch GT, Brothers MJ, Nechemias C, Smith H (1982) Infection and diabetes: the case for glucose control. Am J Med 72(3):439–450CrossRefPubMedGoogle Scholar
  12. Robert-Gangneux F, Darde ML (2012) Epidemiology of and diagnostic strategies for toxoplasmosis. Clin Microbiol Rev 25(2):264–296. doi: 10.1128/CMR.05013-11 CrossRefPubMedPubMedCentralGoogle Scholar
  13. Saki J, Khademvatan S, Soltani S, Shahbazian H (2013) Detection of toxoplasmosis in patients with end-stage renal disease by enzyme-linked immunosorbent assay and polymerase chain reaction methods. Parasitol Res 112(1):163–168. doi: 10.1007/s00436-012-3120-6 CrossRefPubMedGoogle Scholar
  14. Saki J, Mohammadpour N, Moramezi F, Khademvatan S (2015) Seroprevalence of Toxoplasma gondii in women who have aborted in comparison with the women with normal delivery in Ahvaz, southwest of Iran. ScientificWorldJournal 2015:764369. doi: 10.1155/2015/764369 CrossRefPubMedPubMedCentralGoogle Scholar
  15. Soltani S, Khademvatan S, Saki J, Shahbazian H (2013) Detection of toxoplasmosis in renal transplant recipients by ELISA and PCR methods in Ahvaz, South-West of Iran. Jundishapur J Microbiol 6(9):e7642. doi: 10.5812/Jjm.7642 Google Scholar
  16. Sullivan WJ Jr, Jeffers V (2012) Mechanisms of Toxoplasma gondii persistence and latency. FEMS Microbiol Rev 36(3):717–733. doi: 10.1111/j.1574-6976.2011.00305.x CrossRefPubMedGoogle Scholar
  17. Varella IS, Wagner MB, Darela AC, Nunes LM, Muller RW (2003) Seroprevalence of toxoplasmosis in pregnant women. J Pediatr 79(1):69–74 (Rio J) Google Scholar
  18. Yad MJY, Jomehzadeh N, Jafar Sameri M, Noorshahi N (2014) Seroprevalence of anti-toxoplasma gondii antibodies among pregnant woman in South Khuzestan, Iran. Jundishapur J Microbiol 7(5):e9998. doi: 10.5812/jjm.9998 Google Scholar
  19. Zangerle R, Allerberger F, Pohl P, Fritsch P, Dierich MP (1991) High risk of developing toxoplasmic encephalitis in AIDS patients seropositive to Toxoplasma gondii. Med Microbiol Immunol 180(2):59–66CrossRefPubMedGoogle Scholar

Copyright information

© Indian Society for Parasitology 2016

Authors and Affiliations

  1. 1.Department of Medical Parasitology, Faculty of MedicineAhvaz Jundishapur University of Medical SciencesAhvazIslamic Republic of Iran
  2. 2.Health Institute, Diabetes Research CenterAhvaz Jundishapur University of Medical SciencesAhvazIslamic Republic of Iran

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