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Journal of Parasitic Diseases

, Volume 40, Issue 3, pp 872–876 | Cite as

The correlation between Toxoplasma gondii infection and Parkinson’s disease: a case-control study

  • Mahmoud Mahami Oskouei
  • Faezeh Hamidi
  • Mahnaz Talebi
  • Mehdi Farhoudi
  • Ali Akbar Taheraghdam
  • Tohid Kazemi
  • Homayoun Sadeghi-Bazargani
  • Esmaeil Fallah
Original Article

Abstract

Toxoplasma gondii is an obligate intracellular parasite that infects all nucleate cells of vertebrates. Human infected by vertical transmission and also using raw or undercooked meat or food and water that contaminated with mature oocysts. Parkinson‘s disease as neurodegenerative disease affects people above 60 years. Due to high prevalence of toxoplasmosis in Iran and evidence about effects of T. gondii on neurodegenerative diseases, this study has been conducted to investigate possible correlation between Toxoplasma and Parkinson’s disease in Iran. Seventy five Parkinson’s patients and equal healthy volunteers were enrolled. After obtaining informed consent and sociodemographic features, 5 ml blood sample were collected and then anti-Toxoplasma IgG and IgM levels were examined by ELISA method. Data was analyzed with Chi-squre and Fisher’s test by usig stata 11 software. Binary logistic regression was used for multivariate analysis in assessing the correlation between toxoplasmosis and Parkinson. Eighty five percent of Parkinson’s group and 90.3 % of control group were positive for anti-Toxoplasma IgG antibody. In this investigation no statically differences were observed between groups and age, gender, residency and using raw or undercooked meat. There is no significant association between IgG positive titer and Parkinson’s disease. However, statistically significant association was found between Parkinson and keeping cat (P = 0.03) as well as the using of undercooked egg (P = 0.004). Although there is high level of anti-Toxoplasma IgG antibody in Parkinson’s patients which reflects chronic Toxoplasma infection; we couldn’t detect any statistical association between T. gondii infection and Parkinson’s disease.

Keywords

Toxoplasma gondii Parkinson’s disease ELISA Iran 

Notes

Acknowledgments

This work was supported fully by Neurosciences Research Center (Grant no: 1303), Tabriz University of Medical Sciences, Tabriz, Iran. This is a report of a database from thesis of Faezeh Hamidi registered in Tabriz University of Medical Sciences.

Conflict of interest

The authors have no conflicts of interest.

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Copyright information

© Indian Society for Parasitology 2014

Authors and Affiliations

  • Mahmoud Mahami Oskouei
    • 1
    • 2
  • Faezeh Hamidi
    • 1
    • 2
  • Mahnaz Talebi
    • 1
  • Mehdi Farhoudi
    • 3
  • Ali Akbar Taheraghdam
    • 3
  • Tohid Kazemi
    • 4
  • Homayoun Sadeghi-Bazargani
    • 5
  • Esmaeil Fallah
    • 2
  1. 1.Neurosciences Research CenterTabriz University of Medical SciencesTabrizIran
  2. 2.Department of Parasitology, Faculty of MedicineTabriz University of Medical SciencesTabrizIran
  3. 3.Department of Neurology, Faculty of MedicineTabriz University of Medical SciencesTabrizIran
  4. 4.Department of Immunology, Faculty of MedicineTabriz University of Medical SciencesTabrizIran
  5. 5.Department of Biostatistics and Epidemiology, Faculty of Health SciencesTabriz University of Medical SciencesTabrizIran

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