Congenital malaria in a neonate: case report with a comprehensive review on differential diagnosis, treatment and prevention in Indian perspective
- 122 Downloads
Although malaria in pregnancy, lactation and congenital malaria can be a disease burden in the endemic zones of Africa and Indian sub-continent, it is still epidemiologically less investigated in India. As it may lead to considerable maternal and perinatal morbidity and mortality, awareness and timely intervention is necessary for desirable outcome and prevention of the condition. Very few reports of congenital malaria are available in the literature from an endemic country like India. Herein we describe a case of congenital malaria from north India in a 21-day neonate. Clinical presentation of this condition in the neonate may offer a considerable diagnostic challenge, and differentiation from vector borne malaria in infants may be important from the management point of view. Hence a review of the differential diagnosis, management and prevention of congenital malaria has been attempted in the Indian perspective.
KeywordsCongenital Neonatal Malaria Sepsis Transplacental Transmission
- Davies HD, Keystone J, Lester ML, Gold R (1992) Congenital malaria in infants of asymptomatic women. Can Med Assoc J 146:1755–1756Google Scholar
- Poespoprodjo JR, Fobia W, Kenangalem E, Hasanuddin A, Sugiarto P, Tjitra E, Anstey NM, Price RN (2011) Highly effective therapy for maternal malaria associated with a lower risk of vertical transmission. J Infect Dis 204:1613–1619. doi: 10.1093/infdis/jir558 CrossRefPubMedCentralPubMedGoogle Scholar
- Villegas L, McGready R, Htway M, Paw MK, Pimanpanarak M, Arunjerdja R, Viladpai-Nguen SJ, Greenwood B, White NJ, Nosten F (2007) Chloroquine prophylaxis against vivax malaria in pregnancy: a randomized, doubleblind, placebo-controlled trial. Trop Med Int Health 12:209–218CrossRefPubMedGoogle Scholar