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Journal of Parasitic Diseases

, Volume 39, Issue 2, pp 345–348 | Cite as

Congenital malaria in a neonate: case report with a comprehensive review on differential diagnosis, treatment and prevention in Indian perspective

  • Preeti RaiEmail author
  • Kaushik Majumdar
  • Sunita Sharma
  • Richa Chauhan
  • Jagdish Chandra
Short Communication

Abstract

Although malaria in pregnancy, lactation and congenital malaria can be a disease burden in the endemic zones of Africa and Indian sub-continent, it is still epidemiologically less investigated in India. As it may lead to considerable maternal and perinatal morbidity and mortality, awareness and timely intervention is necessary for desirable outcome and prevention of the condition. Very few reports of congenital malaria are available in the literature from an endemic country like India. Herein we describe a case of congenital malaria from north India in a 21-day neonate. Clinical presentation of this condition in the neonate may offer a considerable diagnostic challenge, and differentiation from vector borne malaria in infants may be important from the management point of view. Hence a review of the differential diagnosis, management and prevention of congenital malaria has been attempted in the Indian perspective.

Keywords

Congenital Neonatal Malaria Sepsis Transplacental Transmission 

References

  1. Ansar W, Bandyopadhyay SM, Chowdhury S, Habib SH, Mandal C (2006) Role of C-reactive protein in complement-mediated hemolysis in malaria. Glycoconj J 23:233–240CrossRefPubMedGoogle Scholar
  2. Crocker IP, Tanner OM, Myers JE, Bulmer JN, Walraven G, Baker PN (2004) Syncytiotrophoblast degradation and the pathophysiology of the malaria-infected placenta. Placenta 25:273–282CrossRefPubMedGoogle Scholar
  3. Davies HD, Keystone J, Lester ML, Gold R (1992) Congenital malaria in infants of asymptomatic women. Can Med Assoc J 146:1755–1756Google Scholar
  4. Del Punta V, Gulletta M, Matteelli A, Spinoni V, Regazzoli A, Castelli F (2010) Congenital Plasmodium vivax malaria mimicking neonatal sepsis: a case report. Malaria J 9:63CrossRefGoogle Scholar
  5. Gillespie SH, Dow C, Raynes JG, Behrens RH, Chiodini PL, McAdam KP (1991) Measurement of acute phase proteins for assessing severity of Plasmodium falciparum malaria. J Clin Pathol 44:228–231CrossRefPubMedCentralPubMedGoogle Scholar
  6. Menendez C, D’alessandro U, Ter Kuile FO (2007) Reducing the burden of malaria in pregnancy by preventive strategies. Lancet Infect Dis 7:126–135CrossRefPubMedGoogle Scholar
  7. Perrault SD, Hajek J, Zhong K, Owino SO, Sichangi M, Smith G, Shi YP, Moore JM, Kain KC (2009) Human immunodeficiency virus co-infection increases placental parasite density and transplacental malaria transmission in Western Kenya. Am J Trop Med Hyg 80:119–125PubMedCentralPubMedGoogle Scholar
  8. Poespoprodjo JR, Fobia W, Kenangalem E, Hasanuddin A, Sugiarto P, Tjitra E, Anstey NM, Price RN (2011) Highly effective therapy for maternal malaria associated with a lower risk of vertical transmission. J Infect Dis 204:1613–1619. doi: 10.1093/infdis/jir558 CrossRefPubMedCentralPubMedGoogle Scholar
  9. Quinn TC, Jacobs RF, Mertz GJ, Hook EW III, Locklsey RM (1982) Congenital malaria a report of four cases and a review. J Pediatr 101:229–232CrossRefPubMedGoogle Scholar
  10. Rasheed FN, Bulmer JN, De Francisco A, Jawla MF, Jakobsen PH, Jepson A, Greenwood BM (1995) Relationships between maternal malaria and malarial immune responses in mothers and neonates. Parasitol Immunol 17:1–10CrossRefGoogle Scholar
  11. Rodriguez-Morales AJ, Arria M, Sanchez E, Vargas M, Piccolo C, Colina R, Franco-Paredes C (2007) Outcomes of imported malaria during pregnancy within Venezuelan states: implications for travel advice. J Travel Med 14:67–71CrossRefPubMedGoogle Scholar
  12. Rodriguez-Morales AJ, Benitez JA, Arria M (2008) Malaria mortality in Venezuela: focus on deaths due to Plasmodium vivax in children. J Trop Pediatr 54:94–101CrossRefPubMedGoogle Scholar
  13. Romand S, Bourée P, Gelez J, Bader-Meunier B, Bisaro F, Dommergues JP (1994) Congenital malaria. A case observed in twins born to an asymptomatic mother. Presse Med 23:797–800 [Article in French]PubMedGoogle Scholar
  14. Sankar J, Menon R, Kottarathara AJ (2010) Congenital malaria––a case report from a non-endemic area. Trop Biomed 27:326–329PubMedGoogle Scholar
  15. Singh N, Saxena A, Shrivastava R (2003) Placental Plasmodium vivax infection and congenital malaria in central India. Ann Trop Med Parasitol 97:875–878CrossRefPubMedGoogle Scholar
  16. Sotimehina SA, Runsewe-Abioduna TI, Oladapob OT, Njokanmac OF, Olanrewajua DM (2008) Possible risk factors for congenital malaria at a Tertiary Care Hospital in Sagamu, Ogun State, South-West Nigeria. J Trop Pediatr 54:313–320CrossRefGoogle Scholar
  17. Valecha N, Bhatia S, Mehta S, Biswas S, Dash AP (2007) Congenital malaria with atypical presentation: a case report from low transmission area in India. Malaria J 6:43CrossRefGoogle Scholar
  18. Villegas L, McGready R, Htway M, Paw MK, Pimanpanarak M, Arunjerdja R, Viladpai-Nguen SJ, Greenwood B, White NJ, Nosten F (2007) Chloroquine prophylaxis against vivax malaria in pregnancy: a randomized, doubleblind, placebo-controlled trial. Trop Med Int Health 12:209–218CrossRefPubMedGoogle Scholar
  19. Wiwanitkit V (2006) Congenital malaria in Thailand, an appraisal of previous cases. Pediatr Int 48:562–565CrossRefPubMedGoogle Scholar

Copyright information

© Indian Society for Parasitology 2013

Authors and Affiliations

  • Preeti Rai
    • 1
    Email author
  • Kaushik Majumdar
    • 1
  • Sunita Sharma
    • 1
  • Richa Chauhan
    • 1
  • Jagdish Chandra
    • 2
  1. 1.Department of PathologyLady Hardinge Medical CollegeNew DelhiIndia
  2. 2.Department of PaediatricsLady Hardinge Medical CollegeNew DelhiIndia

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