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Para-clinico-pathological observations of insidious incidence of canine hepatozoonosis from a mongrel dog: a case report

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Abstract

A rare case of canine hepatozoonosis in a mongrel dog with para-clinico-pathological observations has been reported. The study included detailed haemato-biochemical changes at two stages, i.e. before treatment and after treatment with adopted therapy. Before therapy, blood picture revealed normocytic hypochromic anaemia and neutrophilic leucocytosis with variable counts of platelets. Thirty-seven percent of neutrophils were found infected with gametocytes of Hepatozoon canis. Following treatment, further decrease in haemoglobin value with a relative increase in lymphocyte count was seen. Biochemically, increase in alkaline phosphatase, blood urea nitrogen and creatinine levels along with hyperproteinemia was seen. The 14 days chemotherapy did not bring a respite for the dog and the level of parasitaemia was 33% after the treatment. The alkaline phosphatase and creatinine level further rose up following therapy with sulphadiazine and clindamycin. Continual study is required to explain the best possible therapeutic combination to deal H. canis.

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References

  • Adelson ME, Rao RV, Tilton RC, Cabets K, Eskow E, Fein L, Occi JL, Mordechai E (2004) Prevalence of Borrelia burgdorferi, Bartonella spp., Babesia microti and Anaplasma phagocytophila in Ixodes scapularis ticks collected in northern New Jersey. J Clin Microbiol 42:2799–2801

    Article  PubMed  Google Scholar 

  • Banerjee PS, Mylonakis ME, Garg R, Vatysa S, Yadav CL (2008) Concurrent hepatozoonosis, monocytic and granulocytic ehrlichiosis in a dog. J Vet Parasitol 22:9–11

    Google Scholar 

  • Baneth G, Weigler B (1997) Retrospective case-control study of hepatozoonosis in dogs in Israel. J Vet Intern Med 11:365–370

    Article  PubMed  CAS  Google Scholar 

  • Baneth G, Harmelin A, Presentev BZ (1995) Hepatozoon canis infection in two dogs. J Am Vet Med Assoc 206:1891–1894

    PubMed  CAS  Google Scholar 

  • Benjamin MM (1985) In: Outline of veterinary clinical pathology, 3rd edn. Iowa State University Press, Iowa, pp 5–15

  • Craig TM, Smallwood JE, Knauer KW, McGrath JP (1978) Hepatozoon canis infection in dogs: clinical, radiographic and hematologic findings. J Am Vet Med Assoc 173:967–972

    PubMed  CAS  Google Scholar 

  • Elias E, Homans PA (2008) Hepatozoon canis infection in dogs: clinical and haematological findings; treatment. J Small Anim Pract 29:59–62

    Google Scholar 

  • Harikrishnan TJ, Chellappa DJ, Pazhanivel N, Sreekumar C, Anna T, Raman M, Rajavelu G (2001) Epizootiology of canine ehrlichiosis in Chennai. Indian J Anim Sci 71:133–135

    Google Scholar 

  • Harikrishnan TJ, Pazhanivel N, Chellappa DJ (2008) Observations on the development of Hepatozoon canis in a dog. J Vet Parasitol 22:35–40

    Google Scholar 

  • Hervas J, Carrasco L, Sierrra MA (1997) Ultrastructural findings in natural canine hepatozoonosis. J Vet Med 44:119–125

    Article  CAS  Google Scholar 

  • Ibrahim ND, Rahamathulla PM, Njoku CO (1989) Neutrophil myeloperoxidase deficiency associated with canine hepatozoonosis. Int J Parasitol 19:915–918

    Article  PubMed  CAS  Google Scholar 

  • James SP (1905) On a parasite found in white corpuscles of the blood of dogs. In: Scientific memoirs by the office of the medical and sanitary departments of the government of India, vol 14. Office of Govt Print, India, pp 1–12

  • Klopfer U, Newman M, Nobel T (1973) Hepatozoon canis in dogs in Israel. Refug Vet 30:116–120

    Google Scholar 

  • Kordick SK, Breitschwerdt EB, Hegarty BC, Southwick KL, Colitz CM, Hancock SI, Bradley JM, Rumbough R, Mcpherson JT, MacCormack JN (1999) Coinfection with multiple tick-borne pathogens in a walker hound kennel in north Carolina. J Clin Microbiol 37:2631–2638

    PubMed  CAS  Google Scholar 

  • Levin ML, Fish D (2000) Acquisition of coinfection and simultaneous transmission of Borrelia burgdorferi and Ehrlichia phagocytophila by Ixodes scapularis ticks. Infect Immunol 68:2183–2186

    Article  CAS  Google Scholar 

  • Mordecai A, Spencer E, Sellon R K (2006) Co-infection with multiple tick borne pathogens. Vet Med Suppl (http://veterinarymedicine.dvm360.com)

  • Neer TM (2006) Canine monocytotropic ehrlichiosis and neorickettsiosis. In: Greene CE (ed) Infectious diseases of the dog and cat, 3rd edn. WB Saunders Co, Philadelphia, pp 203–216

    Google Scholar 

  • Panciera RJ, Gatto NT, Crystal MA, Helman RG, Ely RW (1997) Canine hepatozoonosis in Oklahoma. J Am Anim Hosp Assoc 33:221–225

    PubMed  CAS  Google Scholar 

  • Pappalardo BL, Correa MT, York CC, Paet CY, Breitschwerdt EB (1997) Epidemiologic evaluation of the risk factors associated with exposure and seroreactivity to Bartonella vinsonii in dogs. Am J Vet Res 58:467–471

    PubMed  CAS  Google Scholar 

  • Pawar SD, Gatne ML (2005) Some haematological and biochemical profiles in canine hepatozoonosis. J Vet Parasitol 19:171–172

    Google Scholar 

  • Priya P, Mathew B, Vijayakumar K, Saseendranath MR (2004) A case report of canine hepatozoonosis. Indian Vet J 81:200–201

    Google Scholar 

  • Sharma RL, Ranga Rao GSC, Varshney JP (1997) Parasitic diseases of canines—an overview. Int J Anim Sci 12:231–244

    Google Scholar 

  • Thomas V, Anguita J, Barthold SW, Fikrig E (2001) Coinfection with Borrelia burgdorferi and the agent of human granulocytic ehrlichiosis alters murine immune responses, pathogen burden, and severity of lyme arthritis. Infect Immunol 69:3359–3371

    Article  CAS  Google Scholar 

  • Tuttle AD, Birkenheuer AJ, Juopperi T, Levy MG, Breitschwerdt EB (2003) Concurrent bartonellosis and babesiosis in a dog with persistent thrombocytopenia. J Am Vet Med Assoc 223:1306–1310

    Article  PubMed  Google Scholar 

  • Voyvoda H, Pasa S, Uner A (2006) Clinical Hepatozoon canis infection in a dog in Turkey. J Small Anim Pract 45:613–617

    Article  Google Scholar 

  • Zeidner NS, Dolan MC, Massung R, Piesman J, Fish D (2000) Coinfection with Borrelia burgdorferi and the agent of human granulocytic ehrlichiosis suppresses IL-2 and IFN gamma production and promotes an IL-4 response in C3H/HeJ mice. Parasite Immunol 22:581–588

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Paramjit Kaur.

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Kaur, P., Deshmukh, S., Singh, R. et al. Para-clinico-pathological observations of insidious incidence of canine hepatozoonosis from a mongrel dog: a case report. J Parasit Dis 36, 135–138 (2012). https://doi.org/10.1007/s12639-011-0092-x

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