ästhetische dermatologie & kosmetologie

, Volume 9, Issue 1, pp 27–30 | Cite as

Ursachensuche erfordert holistischen Ansatz

Umweltinduzierte (extrinsische) Hautalterung

  • Jean Krutmann
  • Tamara Schikowski
  • Anke Hüls
  • Andrea Vierkötter
  • Susanne Grether-Beck
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Schaut man in einem dermatologischen Lehrbuch nach, so wird der Begriff extrinsische Hautalterung in der Regel synonym verwendet mit „Lichtalterung“ der Haut. Unbestreitbar ist, dass eine chronische Bestrahlung mit ultraviolettem Licht, insbesondere als Bestandteil des natürlichen Sonnenlichtes, einen, wenn nicht den wesentlichen Grund für umweltinduzierte Hautalterungsprozesse darstellt. In den letzten Jahren ist aber sehr deutlich geworden, dass weitere Umweltfaktoren am vorzeitigen Alterungsprozess der Haut kausal beteiligt sind.

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Literatur

  1. 1.
    Calles C, Schneider M, Macaluso F, Benesova T, Krutmann J, Schroeder P (2010) Infrared A radiation influences the skin fibroblast transcriptome: mechanisms and consequences. J Invest Dermatol 130:1524–1536CrossRefPubMedGoogle Scholar
  2. 2.
    Cho S, Lee MJ, Kim MS et al (2008) Infrared plus visible light and heat from natural sunlight participate in the expression of MMPs and type I procollagen as well as infiltration of inflammatory cell in human skin in vivo. J Dermatol Sci 50:123–133CrossRefPubMedGoogle Scholar
  3. 3.
    Duteil L, Cardot-Leccia N, Queille-Roussel C, Maubert Y, Harmelin Y, Boukari F, Ambrosetti D, Lacour JP, Passeron T (2014) Differences in visible light-induced pigmentation according to wavelengths: a clinical and histological study in comparison with UVB exposure. Pigment Cell Melanoma Res 27(5):822–826CrossRefPubMedGoogle Scholar
  4. 4.
    Grether-Beck S, Marini A, Jaenicke T, Krutmann J (2014) Photoprotection of human skin beyond ultraviolet radiation. Photodermatol Photoimmunol Photomed 30:167–174CrossRefPubMedGoogle Scholar
  5. 5.
    Grether-Beck S, Marini A, Jaenicke T, Krutmann J (2015) Effective photoprotection of human skin against infrared A radiation by topically applied antioxidants: results from a vehicle controlled, double-blind, randomized study. Photochem Photobiol 91:248–250CrossRefPubMedGoogle Scholar
  6. 6.
    Haarmann-Stemmann T, Esser Ch, Krutmann J (2015) The Janus-faced role of Aryl Hydrocarbon Receptor (AHR) signaling in skin: consequences for prevention and treatment of skin disorders. J Invest Dermatol. 135:2572–2576CrossRefPubMedGoogle Scholar
  7. 7.
    Hüls A, Vierkötter A, Gao W, Krämer U, Yang Y, Ding A, Stolz S, Matsui M, Kan H, Wang S, Jin L, Krutmann J, Schikowski T (2016) Traffic related air pollution contributes to development of facial lentigines: further epidemiological evidence from Caucasians and Asians. J Invest Dermatol (in press)Google Scholar
  8. 8.
    Hüls A, Schikowski T, Krämer U, Sugiri D, Stolz S, Vierkoetter A, Krutmann J (2015) Ozone exposure and extrinsic skin aging: results from the SALIA cohort. Abstract, J Invest Dermatol 135:S49–S57. doi: 10.1038/jid.2015.70CrossRefGoogle Scholar
  9. 9.
    Kim HH, Lee MJ, Lee SR et al (2005) Augmentation of UV-induced skin wrinkling by infrared irradiation in hairless mice. Mech Ageing Dev 126:1170–1177CrossRefPubMedGoogle Scholar
  10. 10.
    Krutmann J, Morita A, Chung JH (2012) Sun exposure: what molecular photodermatology tells us about its good and bad sides. J Invest Dermatol 132:976–984CrossRefPubMedGoogle Scholar
  11. 11.
    Krutmann J, Liu W, Li L, Pan X, Crawford M, Sore G, Seite S (2014) Pollution and skin: from epidemiological and mechanistic studies to clinical implications. J Dermatol Sci 76:163–168CrossRefPubMedGoogle Scholar
  12. 12.
    Liebel F, Kaur S, Ruvolo E, Kollias N, Southall MD (2012) Irradiation of skin with visble light induces reative oxygen species and matrix-degrading enzymes. J Invest Dermatol 132(7):1901–1907CrossRefPubMedGoogle Scholar
  13. 13.
    Mahmoud BH, Ruvolo E, Hexsel CL, Liu Y, Owen MR, Kollias N, Lim HW, Hamzavi ICH (2010) Impact of long-wavelength UVA and visible light on melanocompetent skin. J Invest Dermatol 130(8):2092–2097CrossRefPubMedGoogle Scholar
  14. 14.
    Nakamura M, Morita A, Seité S, Haarmann-Stemmann T, Grether-Beck S, Krutmann J (2015) Environment-induced lentigines: formation of solar lentigines beyond ultraviolet radiation. Exp Dermatol 24:407–411CrossRefPubMedGoogle Scholar
  15. 15.
    Schroeder P, Lademann J, Darvin ME et al (2008) Infrared radiation-induced matrixmetalloproteinase in human skin: implications for protection. J Invest Dermatol 128:2491–2497CrossRefPubMedGoogle Scholar
  16. 16.
    Schroeder P, Calles C, Benesova T, Macaluso F, Krutmann J (2010) Photoprotection beyond ultraviolet radiation-effective sun protection has to include protection against infrared A radiationinduced skin damage. Skin Pharmacol Physiol 23:15–17CrossRefPubMedGoogle Scholar
  17. 17.
    Tigges J, Haarmann-Stemmann T, Vogel CFA, Grindel A, Huebenthal U, Brenden H, Grether-Beck S, Vielhaber G, Johncock W, Krutmann J, Fritsche E (2014) The new aryl hydrocarbon receptor (AhR) antagonist E/Z-2-benzylindene-5,6-dimethoxy-3,3-dimethylindan-1-one (BDDI) protects against UVB-induced signal transduction. J Invest Dermatol 134(2):556–559CrossRefPubMedGoogle Scholar
  18. 18.
    Vierkötter A, Schikowski T, Ranft U, Sugiri D, Matsui M, Kraemer U, Krutmann J (2010) Airborne particle exposure and extrinsic skin aging. J Invest Dermatol 130:2719–2726CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  • Jean Krutmann
    • 1
  • Tamara Schikowski
    • 1
  • Anke Hüls
    • 1
  • Andrea Vierkötter
    • 1
  • Susanne Grether-Beck
    • 1
  1. 1.IUF — Leibniz-Institut für Umweltmedizinische ForschungHeinrich-Heine-Universität, Düsseldorf gGmbH, Auf’m HennekamDüsseldorfDeutschland

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