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Effective and Rapid Synthesis of Pyrido[2,3-d:6,5-d′]Dipyrimidines Catalyzed by a Mesoporous Recoverable Silica-Based Nanomaterial

  • Alireza KohzadianEmail author
  • Abdolkarim ZareEmail author
Original Paper


A simple, rapid and effective protocol for the synthesis pyrido[2,3-d:6,5-d′]dipyrimidines has been developed via the one-pot multi-component reaction of arylaldehydes, 2-thiobarbituric acid and NH4OAc using nano-[SiO2-R-NMe2SO3H][Cl] as a mesoporous nanaocatalyst in solvent-free conditions. The remarkable features of this protocol include superiority relative to the reported methods in terms of two or more of these items: the reaction times, yields, the reaction temperature and conditions.

Graphical Abstract

Effective and rapid synthesis of pyrido[2,3-d:6,5-d′]dipyrimidines catalyzed by a mesoporous recoverable silica-based nanomaterial.


Pyrido[2,3-d:6,5-d′]dipyrimidines. Nano-[SiO2-R-NMe2SO3H][cl]. Mesoporous nanocatalyst. Multi-component reaction. Solvent-free 


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The authors thank Research Council of Payame Noor University for the support of this work.

Supplementary material

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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Department of ChemistryPayame Noor UniversityTehranIran

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